Not exact matches
Furthermore, the membrane microdomains induced by BAR domains are expected to function as diffusion barriers, which may for example trap membrane - associated receptor and
cargo molecules at the
endocytic bud.
Syp1 is a conserved
endocytic adaptor that contains domains involved in
cargo selection and membrane tubulation.
Aspergillus nidulans flippase DnfA is
cargo of the
endocytic collar and plays complementary roles in growth and phosphatidylserine asymmetry with another flippase, DnfB.
We thus propose a molecular hypothesis — termed the GL - Lect hypothesis — on how GlycoLipids and Lectins drive the formation of compositional nanoenvrionments from which the
endocytic uptake of glycosylated
cargo proteins is operated via clathrin - independent carriers.
We hypothesized that certain lectins link glycosylated
cargo proteins and glycosphingolipids into molecular nanoenvironments from which
endocytic pits are formed without the help of the cytosolic clathrin machinery (Figure 1).