A host of
endocytic processes has been described at the plasma membrane of eukaryotic cells.
In this review, we first summarize these contributions by extracellular determinants to
the endocytic process.
Not exact matches
The contribution of extracellular determinants to the construction of
endocytic pits has received much less attention, depite the fact that (glyco) sphingolipids are exoplasmic leaflet fabric of membrane domains, termed rafts, whose contributions to predominantly clathrin - independent internalization
processes is well recognized.
Thus, the
endocytic machinery appears to act as a «sensor gauge» capable of triggering diverse biological
processes depending on the intensity of the stimulus received by the cell.
Our group has discovered two protein - protein interaction networks that sit at the heart of numerous
endocytic and trafficking
processes: the EH (Eps15 Homology) and monoUb networks (9 - 13).