Sentences with phrase «endocytic proteins»

Finally, we are undertaking a vast mutational analysis of endocytic proteins in cancer, to define genetic alterations affecting the endocytic machinery.

Using automated high - content superresolution imaging and quantitative data analysis, we determined how more than a dozen endocytic proteins are organised at the nanoscale.

Figure 2: Left: dual - colour diffraction limited image of endocytic proteins in yeast.

Inactivation of Tor proteins affects the dynamics of endocytic proteins in early stage of endocytosis.

The RCP — Rab11 complex regulates endocytic protein sorting.

Both Notch and p53 signalling are implicated in stem cell self - renewal (18, 19), and the endocytic protein Numb is connected to both these signalling pathways.

Not exact matches

The Loyola study is titled, «Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins.»

However, endocytic waves may be initiated by clathrin through a positive feedback mechanism between clathrin and downstream proteins which includes actin regulating proteins as well as membrane proteins such as PIP3.

The work, led by Assistant Professor Wu Min, showed how a major endocytic pathway mediated by the protein clathrin, was found to commence with periodic traveling waves of clathrin, which were coupled temporally and spatially to downstream cortical actin waves.

WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics.

Endocytic Adaptor Protein Epsin Is Elevated in Prostate Cancer and Required for Cancer Progression.

However, approximately 40 % of human (and most eukaryotic) proteins localize to chemically distinct subcellular environments, including the organelles that compose the secretory pathway, endocytic vesicles, mitochondria, lysosomes or they are secreted into the extracellular milieu.

We thus propose a molecular hypothesis — termed the GL - Lect hypothesis — on how GlycoLipids and Lectins drive the formation of compositional nanoenvrionments from which the endocytic uptake of glycosylated cargo proteins is operated via clathrin - independent carriers.

We hypothesized that certain lectins link glycosylated cargo proteins and glycosphingolipids into molecular nanoenvironments from which endocytic pits are formed without the help of the cytosolic clathrin machinery (Figure 1).

In the Endocytic Trafficking and Intracellular Delivery team we study the cell biology of carbohydrate - binding proteins (lectins) at the level of cellular entry though clathrin - independent endocytosis, retrograde sorting on early endosomes, and translocation to the cytosol.

Our group has discovered two protein - protein interaction networks that sit at the heart of numerous endocytic and trafficking processes: the EH (Eps15 Homology) and monoUb networks (9 - 13).