Beclin1 - binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and
endocytic trafficking.
In collaboration with E. Tartour Group (Georges Pompidou European Hospital, Inserm),
the Endocytic Trafficking and Intracellular Delivery Group led by L. Johannes (Inserm / CNRS / Institut Curie) discovered nasal anti-cancer vaccines would stimulate a population...
In
the Endocytic Trafficking and Intracellular Delivery team we study the cell biology of carbohydrate - binding proteins (lectins) at the level of cellular entry though clathrin - independent endocytosis, retrograde sorting on early endosomes, and translocation to the cytosol.
Comparisons of the cytoskeleton and
endocytic trafficking systems with those of humans and other eukaryotic organisms reveal major differences.
Interpretation of the FGF8 morphogen gradient is regulated by
endocytic trafficking.
Epitope - tagged dopamine transporter knock - in mice reveal rapid
endocytic trafficking and filopodia targeting of the transporter in dopaminergic axons.
Not exact matches
Sphingosine Kinase 1 Cooperates with Autophagy to Maintain
Endocytic Membrane
Trafficking.
Endocytosis has traditionally been viewed as a mechanism for achieving signal attenuation: activated cell surface receptors are internalised and
trafficked through
endocytic vesicles to lysosomes, where they are degraded.
Our group has discovered two protein - protein interaction networks that sit at the heart of numerous
endocytic and
trafficking processes: the EH (Eps15 Homology) and monoUb networks (9 - 13).