Sentences with phrase «endocytosis of»

We are currently defining the mechanistic role of Numb in the endocytosis of Notch.

We are also investigating endocytosis of the cell surface receptor, Notch, a protein involved in cell fate specification (6).

We have established that clathrin - dependent endocytosis of the type - I interferon (IFN - α / β) receptor (IFNAR) is required for JAK / STAT signalling.

Endocytosis of Ligand - Activated Sphingosine 1 - Phosphate Receptor 1 Mediated by the Clathrin - Pathway.

Sphingosine 1 - phosphate - induced motility and endocytosis of dendritic cells is regulated by SWAP - 70 through RhoA.

How carrier size and valency modulate receptor - mediated signaling: understanding the link between binding and endocytosis of ICAM -1-targeted carriers.

Protein kinase C - dependent ubiquitination and clathrin - mediated endocytosis of the cationic amino acid transporter CAT - 1.

Three ubiquitin conjugation sites in the amino terminus of the dopamine transporter mediate protein kinase C — dependent endocytosis of the transporter.

Multiple mechanisms collectively regulate clathrin - mediated endocytosis of the epidermal growth factor receptor.

These findings provide a previously unrecognized mechanism for receptor recruitment of β - arrestin and demonstrate that Dvl plays an important role in the endocytosis of frizzled, as well as in promoting signaling.

Wnt proteins, regulators of development in many organisms, bind to seven transmembrane — spanning (7TMS) receptors called frizzleds, thereby recruiting the cytoplasmic molecule dishevelled (Dvl) to the plasma membrane.Frizzled - mediated endocytosis of Wg (a Drosophila Wnt protein) and lysosomal degradation may regulate the formation of morphogen gradients.

Endocytosis of Frizzled 4 (Fz4) in human embryonic kidney 293 cells was dependent on added Wnt5A protein and was accomplished by the multifunctional adaptor protein β - arrestin 2 (βarr2), which was recruited to Fz4 by binding to phosphorylated Dvl2.

β - Arrestins are required for endocytosis of Smo and signaling to Gli transcription factors.

Not exact matches

Among all the genes that control endocytosis, the authors of the study focused specifically on one, called RAB7; this gene is highly expressed in melanoma cells.

Chao also showed that excess choline inhibited endocytosis, mimicking the effects of CTL1 loss and suggesting that a critical CTL1 function is to sequester choline into endosomes.

Dr. Taraska's lab studies the structural cell biology of exocytosis and endocytosis with advanced imaging methods including live cell microscopy, superresolution fluorescence, and electron microscopy.

To initiate endocytosis, adaptor proteins need to recognize specific areas of the membrane to be internalized.

While proteins involved in endocytosis, such as clathrin, are conserved across the animal and plant kingdoms, the members of the TPLATE complex appears specially designed for plants.

While working on his Ph.D., Dr. Taraska investigated the processes of triggered exocytosis and endocytosis in neuroendocrine cells with high - resolution microscopy methods.

Using state - of - the - art techniques, researchers of VIB, Ghent University and the Max - Planck - Institute in Potsdam - Golm have now identified an adaptor protein complex which is essential for endocytosis and which only exists in plants.

The new method will allow cell biologists to accurately study the timing of endocytosis and what proteins are required.

A team at Warwick Medical School, University of Warwick, has managed to trigger clathrin - mediated endocytosis in the lab.

The latest frontier in this search for cancer telltales is the cellular process of endocytosis, which is the way cells take outside materials like proteins inside.

Researchers from the Mechanobiology Institute, Singapore (MBI) at the National University of Singapore, report that endocytosis, which was previously thought to be a random process, actually occurs in a coordinated manner through collective dynamics.

There are multiple modes of endocytosis, of which Clathrin - Mediated Endocytosis (CME) is a majendocytosis, of which Clathrin - Mediated Endocytosis (CME) is a majEndocytosis (CME) is a major example.

But by hierarchical clustering of observed alterations in endocytosis, the researchers identified two distinct cancer phenotype clusters, one marked by mutations in the oncogene KRAS in mesenchymal cells and the other by changes in epithelial cells.

A cell can change the amount of these cell surface proteins by internalizing small portions of the membrane through endocytosis.

The UT Southwestern researchers monitored endocytosis in NSCLCs and found significant heterogeneity among the various cell lines, underlining the astounding variety and personal nature of cancer types.

The link between endocytosis and generation of cortical actin waves may provide deeper insight into how cells maintain the composition and dynamics of the plasma membrane.

This study reports for the first time the occurrence of collective dynamics of endocytosis and shows how this regulates the onset of cortical actin waves.

Endocytosis is not normal in cancer cells but how dysregulated the process is in cancer cells has just been revealed by Sarah Elkin and colleagues in the University of Texas (UT) Southwestern Medical Center lab of Sandra Schmid.

A solution to the problem of creating endocytosis on demand is being compared to «hotwiring» a car.

The team also solved the problem of knowing where endocytosis will happen on the cell.

In particular, this study demonstrates the capability to track structural dynamics and remodeling of the cell surface, such as morphogenesis of filopodia, membrane ruffles, pit formation or endocytosis, in response to environmental stimulants.

Moreover, examination of the role of Mcf1 can be dissected genetically using mutants that either interfere with its endocytosis into target cells, or Rac signalling mutants that hint at early and unexpected Mcf1 mediated effects on the phagocyte cytoskeleton.

Apparently, too much alpha - synuclein in the nerve terminal causes microtubules to over-assemble and somehow get in the way of endocytosis.

The retrieval of an emptied vesicle membrane is called «endocytosis,» and it is this process that an overabundance of alpha - synuclein disrupts.

A deeper look into the mechanism by which alpha - synuclein inhibits endocytosis revealed toxic effects of the over-assembly of microtubules.

«If you inhibit [endocytosis in the nerve terminal], then the vesicle recycling becomes slower and the supply of the vesicles is inhibited,» OIST Professor Tomoyuki Takahashi from the Cellular and Molecular Synaptic Function Unit explains.

Researchers at the Okinawa Institute of Science and Technology Graduate University (OIST) have found that the protein hinders a key step involved in the transmission of neuronal signals, which is essential for higher - brain functioning: vesicle endocytosis at the nerve terminal.

As all yeast integral PM components that we observed exhibit very slow lateral mobility we expect that delivery and removal of membrane components via exo - and endocytosis have a major influence on the final lateral localization patterns.

Endocytosis by random initiation and stabilization of clathrin - coated pits.

Our studies on the molecular mechanisms of endocytosis led to the discovery that the small GTPase Rab5 is a master regulator of early endosome biogenesis.

Giovanni Marsico (Zerial, MPG)-- «Analysis of the interplay between endocytosis and cell morphology through the development of computational methods» (2011)

Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome.

High advanced glycation end - products overwhelm innate defenses of enzymes and receptor - mediated endocytosis and promote cell damage via the pro-inflammatory and pro-oxidant receptor for advanced glycation end - products.

RNA interference screen reveals an essential role of Nedd4 — 2 in dopamine transporter ubiquitination and endocytosis.

Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis.

Live - cell fluorescence imaging reveals high stoichiometry of Grb2 binding to the EGF receptor sustained during endocytosis.

Clathrin light chain directs endocytosis by influencing the binding of the yeast Hip1R homologue, Sla2, to F - actin.