Sentences with phrase «endocytosis on»

A solution to the problem of creating endocytosis on demand is being compared to «hotwiring» a car.

Not exact matches

Endocytosis of Frizzled 4 (Fz4) in human embryonic kidney 293 cells was dependent on added Wnt5A protein and was accomplished by the multifunctional adaptor protein β - arrestin 2 (βarr2), which was recruited to Fz4 by binding to phosphorylated Dvl2.

Among all the genes that control endocytosis, the authors of the study focused specifically on one, called RAB7; this gene is highly expressed in melanoma cells.

While working on his Ph.D., Dr. Taraska investigated the processes of triggered exocytosis and endocytosis in neuroendocrine cells with high - resolution microscopy methods.

The team also solved the problem of knowing where endocytosis will happen on the cell.

Consequently, many cellular processes such as endocytosis, migration and morphogenesis rely on proteins that bind directly to membranes and sculpt them into desired shapes.

Moreover, examination of the role of Mcf1 can be dissected genetically using mutants that either interfere with its endocytosis into target cells, or Rac signalling mutants that hint at early and unexpected Mcf1 mediated effects on the phagocyte cytoskeleton.

As all yeast integral PM components that we observed exhibit very slow lateral mobility we expect that delivery and removal of membrane components via exo - and endocytosis have a major influence on the final lateral localization patterns.

Our studies on the molecular mechanisms of endocytosis led to the discovery that the small GTPase Rab5 is a master regulator of early endosome biogenesis.

Exosome Uptake Depends on ERK1 / 2 - Heat Shock Protein 27 Signaling and Lipid Raft - mediated Endocytosis Negatively Regulated by Caveolin - 1.

Visualization of Rab5 activity in living cells by FRET microscopy and influence of plasma - membrane - targeted Rab5 on clathrin - dependent endocytosis.

Scaling great walls When they both started at Penn, Lee had a project on the effects of nerve growth factor on PC12 cells, and Trojanowski was studying axonal transport and endocytosis.

We will also focus on lipid signalling and lipid - controlled cell biology, and examine the effect of sphingo - and phospholipids on endocytosis, lipid trafficking, and insulin secretion.

In the Endocytic Trafficking and Intracellular Delivery team we study the cell biology of carbohydrate - binding proteins (lectins) at the level of cellular entry though clathrin - independent endocytosis, retrograde sorting on early endosomes, and translocation to the cytosol.

Recently, he has been focusing on the regulation of a family of yeast purine - cytosine permeases, including the transcriptional controls over their expression, and how, after these proteins bind to their cargo, they are targeted by the ubiquitin system for endocytosis and delivery to the vacuole.

However, we have recently discovered that, depending on the concentration of ligand, the EGFR may also be internalised via an alternative clathrin - independent / lipid raft - dependent endocytic route: non-clathrin endocytosis (NCE)(4).

Coated pits, associated with endocytosis, were also present on iPS - RPE cells (Fig. 2E).

Due to constitutive endocytosis, only small surface TCRβ / CD3 amounts are detectable on DN3 and DN3 - 4 cells (Panigada et al., 2002).

Specific inhibition of Vps34 activity in the complex form might differentiate the effect on autophagy or endocytosis.