Sentences with phrase «endoderm formation»
«Discovering a molecular pathway of endoderm formation was unchartered territory in itself,» said Stainier.
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The researchers found that maternal gdf3 is required for Ndr1 and Ndr2 to signal at the levels necessary to properly induce the formation of mesoderm and endoderm cells in early zebrafish embryos.
The researchers came upon their finding serendipitously, after working out the molecular pathway, or succession of genes, that prompt the early - stage formation of the endoderm, one of the three layers of cells that form the developing embryo.
3) The co-authors of the role of the endoderm in heart formation study, published Developmental Biology, (September) were Jonathan Alexander, Michael Rothenberg, a graduate student in Jun's lab, and Gilbert L. Henry, PhD, of the Department of Molecular and Cellular Biology at Harvard University.
Novocell scientists pioneered a differentiation process that successfully engineers hES cells into definitive and pancreatic endoderm cells necessary for pancreas formation.
Taken together our data support the notion that the reversible and immediate early PrEn state marked by low - level transcription at the Hex locus is biased towards the formation of extra-embryonic endoderm.
Moreover, ES cell differentiation in vitro recapitulates events that take place during early embryonic development including the formation of the three germ layers of ectoderm, mesoderm and endoderm, and the emergence of endothelial, hematopoietic, cardiac, neuronal and hepatic or pancreatic cells [8], [9].
Analysis of Oct4 protein expression in differentiated Ara - C cultures (DACs) showed a slight increase of Oct4 protein by day four of aggregate formation (Figure 1C), consistent with previous reports examining Oct4 mRNA dynamics [22] and the finding that primitive endoderm differentiation is accompanied by a transient increase in Oct4 protein levels [23].