Sentences with phrase «endoderm states»

The ability of Nanog to suppress early Hex positive endoderm states is consistent with both the mutually exclusive nature of Nanog and Gata6 expression in vivo [17] and the ability of Nanog to suppress Gata6 positive PrEn differentiation, in vitro [39].

Not exact matches

Here we use a transgenic allele designed to detect low level transcription in the primitive endoderm lineage as a tool to identify an immediate early endoderm - like ES cell state.

Taken together our data support the notion that the reversible and immediate early PrEn state marked by low - level transcription at the Hex locus is biased towards the formation of extra-embryonic endoderm.

We show that the fraction of cells present within this state is influenced by factors that both promote and suppress primitive endoderm differentiation, but conditions that support ES cell self - renewal prevent their progression into differentiation and support an equilibrium between this state and at least one other that resembles the Nanog positive inner cell mass of the mammalian blastocysts.

A more recent study showed overlapping expression of nanog with GATA - 6 and a Pdgfra reporter, markers of the primitive endoderm lineage, from the morula to the 64 cell stages [8], suggesting a gradual transition from a pluripotency program to a committed state.