Sentences with phrase «endogenous abl»

To examine the functional role of ABL kinases in these cells, we depleted endogenous ABL kinases with previously characterized short hairpin RNAs (shRNAs) specific against ABL1 and ABL2 (20).

Double knockdown of ABL1 and ABL2 was required to decrease the phosphorylation of CrkL by more than 90 %, which indicates inactivation of the endogenous ABL kinases (Fig. 2K).