An anti-cancer diet also needs to be low or moderate in complete protein and high - insulemic index foods (to reduce growth promoting IGF - 1), and perhaps low in methionine specifically while high in fiber, phytochemical hormetics (to induce
endogenous antioxidant responses and toxin removal), epigenetically active compunds (to reexpress tumor suppressor genes for induce cellular senescence or apoptosis), inflammation inhibitors, and antiangiogenetic compounds.
Not exact matches
Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of
endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich
antioxidant defenses in the lung fluid, secondarily generated oxidization products of
endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in
endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular
responses) rather than ROS derived directly from PM and its constituents.
The Adaptive Stress
Response includes well over 100 cytoprotective proteins that participate in production of
endogenous antioxidants, DNA & protein repair, damaged protein removal, toxin export, metal chelation, inflammation inhibition, or are themselves
antioxidants.
Our ancestors evolved to deal with these exobiotic toxins with robust
endogenous antioxidant and detoxification
responses, and in their absence (eg, in a highly processed diet), our cells don't get the expected cues to ramp up defenses.
In
response to the constant oxidative stress produced during chronic exercise training, a well - trained individual will have a more highly developed
endogenous antioxidant system to combat the free radical production compared to a sedentary individual (Rodriguez, DiMarco and Langley, 2009).