In response to the constant oxidative stress produced during chronic exercise training, a well - trained individual will have a more highly developed
endogenous antioxidant system to combat the free radical production compared to a sedentary individual (Rodriguez, DiMarco and Langley, 2009).
A growing body of evidence indicates that consuming large quantities of antioxidants like vitamin C, E, and β - carotene can interfere with the body's
endogenous antioxidant system.
Not exact matches
Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450
systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of
endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich
antioxidant defenses in the lung fluid, secondarily generated oxidization products of
endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in
endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.
Food science: - Sulfer is one of the most abundant mineral elements in the human body - Sulfer is required for the synthesis of glutathione, one of our
endogenous (we make our own)
antioxidants — an
antioxidant that neutralizes free radicals, helps control blood pressure and inflammation, and helps the liver process toxins - Sulfur is essential for Taurine synthesis — taurine is essential to our Central nervous
system and the workings of our cardiovascular
system - Sulfur helps bind the amino acid chains that form insulin.
Molecular hydrogen appears to stimulate the production of
endogenous antioxidants via the Nrf2 Pathway, meaning it up - regulates the body's own
antioxidant system.
A healthy diet should support the entire
endogenous oxidative
system, as
antioxidants often work together.