"Endogenous antioxidants" refers to natural substances produced by our bodies that help protect our cells against harmful particles called free radicals. These antioxidants work to keep our body healthy and prevent damage to our cells.
Full definition
Molecular hydrogen appears to stimulate the production
of endogenous antioxidants via the Nrf2 Pathway, meaning it up - regulates the body's own antioxidant system.
In response to the constant oxidative stress produced during chronic exercise training, a well - trained individual will have a more highly developed
endogenous antioxidant system to combat the free radical production compared to a sedentary individual (Rodriguez, DiMarco and Langley, 2009).
An anti-cancer diet also needs to be low or moderate in complete protein and high - insulemic index foods (to reduce growth promoting IGF - 1), and perhaps low in methionine specifically while high in fiber, phytochemical hormetics (to induce
endogenous antioxidant responses and toxin removal), epigenetically active compunds (to reexpress tumor suppressor genes for induce cellular senescence or apoptosis), inflammation inhibitors, and antiangiogenetic compounds.
The first is prevention
with endogenous antioxidants — superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase work together to stabilize then break down the free radical so it can be used to regenerate glutathione, the body's most potent antioxidant.
According to one study, milk thistle protected the heart
from endogenous antioxidant enzymes, and protected the heart from a further drop in blood pressure.
Our cortisol is highest in the morning (around 6 - 8 am) and declines throughout the day as melatonin, our body's most
potent endogenous antioxidant, begins to rise and eventually puts us to sleep.
Alpha - lipoic acid, another
powerful endogenous antioxidant, increases glutathione production in the body, as does the sleep hormone melatonin — which stimulates production of the antioxidant enzyme glutathione peroxidase.
Mechanism The researchers suspect that physical exercise generates free radicals, and as a result the body produces
more endogenous antioxidants.
Moreover, reactive nitrogen and oxygen species (RNOS) are used extensively in cellular signalling, and cells adaptively
regulate endogenous antioxidants on short time scales to respond to deletorious spikes of RNOS faster than we could ever achieve with dietary antioxidants.
Our ancestors evolved to deal with these exobiotic toxins with
robust endogenous antioxidant and detoxification responses, and in their absence (eg, in a highly processed diet), our cells don't get the expected cues to ramp up defenses.
The cells reacted to this by stepping up their production
of endogenous antioxidants, such as the enzymes superoxide dismutase [SOD] and catalase.
Mussels are one of the better sources of manganese, a mineral that helps oppose iron overload and figures prominently in the production of a
vital endogenous antioxidant that protects against the kind of oxidative stress that leads to diabetic complications (whew!).
But what it does is induces
the endogenous antioxidant process and also has neuroprotection.
Thioredoxin - 1 (Trx1) is
an endogenous antioxidant protein important for redox regulation and participates in the regulation of apoptosis through the inhibition of apoptosis signal - regulating kinase - 1 (Ask - 1).
Endogenous antioxidants are the body's own line of defenses against free radicals.
Glutathione stands out among
the endogenous antioxidants since it is the cell's protector and major defense against invaders and free radicals.
Other
endogenous antioxidants are superoxide dismutase (SOD) and catalase.
Endogenous antioxidants are those that are made inside the body.
Creatine also reduced the production of
the endogenous antioxidant glutathione.
It is one of the body's
endogenous antioxidants, along with superoxide dismutase (SOD), CoEnzyme Q10 (CoQ10), alpha lipoic acid and Catalase.
To support the efforts of
the endogenous antioxidants, we as humans need to consume antioxidants through a diet rich in functional antioxidant nutrition.
Glutathione is considered our most important
endogenous antioxidant.
And it is the job of our body's
endogenous antioxidants to quench them.
Endogenous antioxidants are the following: Glutathione, the body's master antioxidant, Coenzyme Q10 and Alpha Lipoic Acid.
Flavonoids also lower blood sugar levels, can restrict angiogenesis, help to keep nitric oxide within a healthy range and raise the body's level of
the endogenous antioxidant glutathione.