Sentences with phrase «endogenous gene expression»

However, these assays are unsuitable for screening primary cells and can not assess impact on endogenous gene expression.

In previous studies, Chen - Yu Zhang's group has reported a striking finding that plant miRNAs are ingested from plant diets and pass through the gastrointestinal tract, enter into the blood, accumulate in tissues and regulate endogenous gene expression in animals.

Not exact matches

MiRNAs are small endogenous noncoding RNAs which negatively regulate gene expression.

The Morris lab is specifically interested in utilizing the recently described endogenous non-coding RNA pathway in human cells to epigenetically modulate gene expression in those genes involved in HIV, cystic fibrosis, and cancer.

Notably, evidence suggests that this endogenous pathway can be utilized to either epigenetically silence or activate a genes expression.

Bach1 has an endogenous ligand, heme, that inhibits Bach1 binding to ARE, thus allowing Nrf2 - mediated gene expression including that of heme - oxygenase - 1 (HMOX1), a well described target of Bach1 repression.

The use of endogenous HMOX1 protein expression as a readout allowed the identification of compounds that specifically derepress Bach1 and induce transcription of an Nrf2 - responsive gene.

In mouse models in which the endogenous Smn1 gene has been knocked out and human versions of SMN2 have been swapped in, the Isis therapy — a so - called «antisense oligonucleotide» — delivered to the mouse central nervous system (CNS) increased the expression of full - length SMN protein in motor neurons, improved muscle strength in behavioral tests and extended the rodents» median lifespan from 16 days to 26 days3.

Here, we hypothesize that XJB -5-131 will lower IOP by decreasing endogenous TGF - Î ² 2 gene expression and protein secretion.

The aim of WICT is the removal from the organismal environment of accumulated cellular and intracellular damage present in the patient's endogenous cells, including telomere depletion, nuclear DNA damage and mutations, mitochondrial DNA damage and mutations, replicative senescence, functionally - deleterious age - related changes in gene expression and accumulated cellular and intracellular aggregates.