On the contrary, recent evidence indicates that XMRV is a contaminant originating from the recombination of two mouse
endogenous retroviruses during passaging of a prostate tumor xenograft (CWR22) in mice, generating laboratory - derived cell lines that are XMRV - infected.
Finally, a 2011 study from Paprotka, et al. provided strong evidence that XMRV is a 22Rv1 - derived laboratory contaminant originating from recombination of two mouse
endogenous retroviruses during serial passage of CWR22 in nude mice [38].
Not exact matches
In 2011, Paprotka, et al. reported that XMRV likely originated through recombination between 2
endogenous murine
retroviruses, PreXMRV - 1 and PreXMRV - 2,
during in vivo passaging of the human prostate cancer xenograft CWR - R1, resulting in establishment of the XMRV - infected 22Rv1 cell line [38].