Protein sequences from 3D7 reference P. falciparum strain were truncated to remove
endogenous signal peptides and sequences corresponding to GPI anchors.
Not exact matches
MALDI - MS analysis revealed an absence of Aβ
signal in non-transgenic animals (Figure 5) at both time points, indicating that detected Aβ
peptides predominantly derive from the human APP transgene expression or reflecting the low level of
endogenous rodent Aβ [51].
In the worm, we are developing tools to monitor neuromodulation at cellular resolution in an intact brain and using them to directly measure
endogenous peptide release and binding to receptors on identified neurons using real - time approaches for imaging neuropeptide
signaling, in order to understand the dynamics of this process in a living animal.
Amphimedon possesses homologues of bilaterian proteins involved in nervous system development (for example, elav - and musashi - like RNA - binding proteins, neural transcription factors), pre - and post-synaptic organization (for example, Discs large) 42,
endogenous and exogenous
signalling (for example, G - protein - coupled receptors (GPCRs)-RRB-, and neuroendocrine secretion, although bilaterian
peptide hormones are not detected (Supplementary Note 8.9).