Sentences with phrase «endometrial cancer by»

Because obesity is known to increase a woman's risk of endometrial cancer by 200 percent, a team of researchers led by oncologist Leena Hilakivi - Clarke of Georgetown Lombardi Comprehensive Cancer Center in Washington, D.C., decided to examine the development of endometrial cancer in obese mice to that in non-obese mice.

Some cancers: Women on the pill reduce their risk of colon cancer by 14 percent and endometrial cancer by 43 percent, per a 2013 study.

The findings reveal that every 5 years of oral contraceptive use reduces the risk of endometrial cancer by about a quarter.

Not exact matches

By contrast, in more than 90 % of endometrial cancers, the gene has undergone hypermethylation, an epigenetic modification that doesn't change its DNA sequence but renders it inactive.

By comparing with other already known factors, HAND2 methylation is by far the most common molecular alteration in endometrial canceBy comparing with other already known factors, HAND2 methylation is by far the most common molecular alteration in endometrial canceby far the most common molecular alteration in endometrial cancer.

We identified patients with mutations that predict phenomenal outcomes in the disease; this is a group of women with endometrial cancer who won't need the financial, physical or emotional toll of chemotherapy at all — they're patients who are probably cured by surgery alone.

However, James notes, a review of data by the World Health Organization's International Agency for Research on Cancer last February concluded that between a quarter and third of all colon, breast, endometrial, kidney, and esophageal cancers globally may trace to excess weight, especially obesity.

Researchers from the Collaborative Group on Epidemiological Studies on Endometrial Cancer estimate that in the past 50 years (1965 - 2014) about 400000 cases of endometrial cancer have been prevented by oral contraceptive use in high - income countries, including about 200000 in the last decade (20Endometrial Cancer estimate that in the past 50 years (1965 - 2014) about 400000 cases of endometrial cancer have been prevented by oral contraceptive use in high - income countries, including about 200000 in the last decade (2005 - Cancer estimate that in the past 50 years (1965 - 2014) about 400000 cases of endometrial cancer have been prevented by oral contraceptive use in high - income countries, including about 200000 in the last decade (20endometrial cancer have been prevented by oral contraceptive use in high - income countries, including about 200000 in the last decade (2005 - cancer have been prevented by oral contraceptive use in high - income countries, including about 200000 in the last decade (2005 - 2014).

In addition, the study, led by investigators in The Cancer Genome Atlas (TCGA) Research Network, revealed four novel tumor subtypes, while also identifying genomic similarities between endometrial and other cancer types, including breast, ovarian, and colorectal caCancer Genome Atlas (TCGA) Research Network, revealed four novel tumor subtypes, while also identifying genomic similarities between endometrial and other cancer types, including breast, ovarian, and colorectal cacancer types, including breast, ovarian, and colorectal cancers.

Permanent discontinuation of study medication was required by protocol for women who developed breast cancer, endometrial pathologic state (hyperplasia not responsive to treatment, atypia, or cancer), deep vein thrombosis (DVT) or PE, malignant melanoma, meningioma, triglyceride level greater than 1000 mg / dL (11.3 mmol / L), or prescription of estrogen, testosterone, or selective estrogen - receptor modulators by their personal physician.

Potential cardioprotection was based on generally supportive data on lipid levels in intermediate outcome clinical trials, trials in nonhuman primates, and a large body of observational studies suggesting a 40 % to 50 % reduction in risk among users of either estrogen alone or, less frequently, combined estrogen and progestin.2 - 5 Hip fracture was designated as a secondary outcome, supported by observational data as well as clinical trials showing benefit for bone mineral density.6, 7 Invasive breast cancer was designated as a primary adverse outcome based on observational data.3, 8 Additional clinical outcomes chosen as secondary outcomes that may plausibly be affected by hormone therapy include other cardiovascular diseases; endometrial, colorectal, and other cancers; and other fractures.3, 6,9

Next, we found that the increase of p21Cip1 / WAF1 expression, which occurs upon LA exposure in a p53 - independent manner, is involved in the apoptotic effects prompted by LA in both breast and endometrial cancer cells.

Blood clots, endometrial hyperplasia and uterine cancer are all caused by oral estrogen tablets, called Premarin, given without progesterone, which historically was the usual practice from 1950 to 1975.

Regular menstural cycles can also reduce the risk for developing endometrial hyperplasia and ovarian cancer, by preventing the uterine lining from becoming too thick.

WHI Study (Second Arm): All the women in the second arm of the WHI study had prior hysterectomies (uterus absent), so they did not need the synthetic progestin, called Provera, which is required to prevent the endometrial cancer caused by Premarin alone.

Over many years, endometrial cancer may result due to continuous stimulation by high levels of estrogen unopposed by progesterone, causing the uterine lining to thicken and fail to properly shed.

This reduction in risk may also extend to ovarian and endometrial cancers, two other types of cancer that are influenced by hormones.

Obesity causes elevated amounts of estrogen (secreted by fat cells) which can drive genesis of certain cancers like breast and endometrial cancer

Moreover, estrogen imposes a risk of endometrial cancer that is largely preventable by progesterone and its analogues.

In clinical trials, Raloxifene (also used for osteoporosis) has been shown to cut the risk of breast cancer by 70 percent without causing endometrial cancer.