Here, we provide novel insights regarding the molecular mechanisms through which LA triggers antiproliferative and pro-apoptotic effects in both breast and
endometrial cancer cells.»
Next, we found that the increase of p21Cip1 / WAF1 expression, which occurs upon LA exposure in a p53 - independent manner, is involved in the apoptotic effects prompted by LA in both breast and
endometrial cancer cells.
Our findings shed new light on the molecular mechanisms through which LA induces antiproliferative and pro-apoptotic responses in both breast and
endometrial cancer cells toward its usefulness in more comprehensive therapeutic approaches.
Cisplatin regulates cell autophagy in
endometrial cancer cells via the PI3K / AKT / mTOR signalling pathway.
The technique also enables the researchers to grow organoids from
endometrial cancer cells.
Not exact matches
The study published in
Cancer Cell shows that exosomes from tumor cells of breast cancer (and other tumor types such as ovarian and endometrial) are different in size and composition than those of healthy
Cancer Cell shows that exosomes from tumor
cells of breast
cancer (and other tumor types such as ovarian and endometrial) are different in size and composition than those of healthy
cancer (and other tumor types such as ovarian and
endometrial) are different in size and composition than those of healthy
cells.
Analysing certain genes in these
cells enabled them to detect 33 per cent of ovarian
cancers and 81 per cent of
endometrial cancers in Pap test specimens collected from 627 women already diagnosed with these diseases.
«In this study, we found that enhanced neuropilin - 1 (NRP - 1) and NEDD9 levels in
endometrial and lung
cancer positively correlated with metastasis, while liver kinase B1 (LKB1) inhibited the migration of
cancer cells.»
This part will enroll subjects with certain types of
endometrial cancer, melanoma, non-small
cell lung
cancer, and renal (kidney)
cancer.
Currently, the CDK9 inhibitor flavopiridol is being evaluated in several phase I and II clinical trials for its anti-
cancer effects either as a single agent or in combination with other drugs in treatment of esophageal
cancer, B -
cell chronic lymphocytic leukemia,
endometrial carcinoma, recurrent / metastatic squamous
cell carcinoma and most relevantly, previously treated locally advanced or metastatic breast
cancer (http://www.cancernetwork.com/review-article/current-clinical-trials-flavopiridol/page/0/2).
Tumor - targeting nanoparticles loaded with a drug that makes
cancer cells more vulnerable to chemotherapy's toxicity could be used to treat an aggressive and often deadly form of
endometrial cancer, according to new research...
Obese woman are the ones most at risk of
endometrial hyperplasia or
cancer (too many or abnormal
cell growth in the lining of the womb) and for this reason the Pill may be their best treatment to help regulate their cycle.
Obesity causes elevated amounts of estrogen (secreted by fat
cells) which can drive genesis of certain
cancers like breast and
endometrial cancer
Over the past several years, studies in
cell cultures and animals have found that metformin appears to slow or stop the growth of a wide range of
cancer cells, including those associated with breast, prostate, lung, and
endometrial cancer.