Sentences with phrase «endoplasmic reticulum function»

Though the UPR usually promotes healthy endoplasmic reticulum function, sustained UPR activation sometimes results in diseases such as atherosclerosis, the deposition of fatty plaques on artery walls, among other conditions.

In this research, the scientists disturbed endoplasmic reticulum function by introducing saturated fatty acids into cells to induce lipotoxic stress.

Not exact matches

In the online issue of the journal Nature, the researchers report a new function of FAM134B in the constant renewal of the endoplasmic reticulum (ER), an important cell organelle.

Fat - induced stress and metabolic overload of the endoplasmic reticulum can alter its function, triggering chronic inflammation, which plays an important role in the development of atherosclerosis.

The UPR is triggered when the normal functions of the endoplasmic reticulum — the cell's largest organelle in charge of making and folding proteins — are compromised.

Moreover, a funnel - shaped pore in the Sec61 oligomer aligned with the exit of a tunnel traversing the large ribosomal subunit, strongly suggesting that both structures function together in the translocation of proteins across the endoplasmic reticulum membrane.

Transit of a CD8 - p24 chimera from the endoplasmic reticulum through the Golgi complex was slowed when the phenylalanine motif was mutated, suggesting that this motif may function as an anterograde transport signal.

Wolfram syndrome is caused by a mutation in the gene encoding a protein called wolframin, which resides in the membrane of the endoplasmic reticulum — another cellular compartment that functions as a manufacturing and packaging system and also acts as a reservoir for calcium ions.

They homed in on the function of the endoplasmic reticulum (ER)-- a «mini-organ» inside cells where proteins and lipids are processed and packaged and undergo quality control before they reach their destinations in the body.

When the research team used pharmaceuticals to inhibit one function of the endoplasmic reticulum (the building of so - called lipoprotein particles that will export fats out of the cell), the gene activation process was inhibited for many key genes and nuclear ruffling was also altered.

In fact, genetic and pharmacological targeting of the IRE - 1 / XBP - 1 pathway of the endoplasmic reticulum stress response, which is critical for antibody production, results in decreased numbers and reduced functions of MDSCs.

Anterograde trafficking of G protein - coupled receptors: function of the C - terminal F (X) 6LL motif in export from the endoplasmic reticulum.

Endoplasmic reticulum - associated mitochondria — cortex tether functions in the distribution and inheritance of mitochondria.

He joined the Polleux lab in 2017 where he studies how the endoplasmic reticulum (ER) and mitochondria networks regulate spatiotemporal dynamics of dendritic calcium in the context of synaptic integration, plasticity, circuit function and behavior.

The Hu laboratory studies endoplasmic reticulum (ER), which has critical functions in lipid synthesis, calcium storage and drug metabolism.

These sub-cellular mini organs do various functions for the cell such as generate energy (mitochondrion) and remove waste products (lysosomes) and make proteins (endoplasmic reticulum).