Sentences with phrase «endoplasmic reticulum stress»

Bottom: Human epithelial cells from breast tissue showing the effects of endoplasmic reticulum stress (blue) which fills the entire cell structure.

The findings reveal a causal chain of events whereby the decreased levels of wolframin protein destabilize the endoplasmic reticulum (causing endoplasmic reticulum stress), thereby reducing calcium release.

Hypertension drug that protects cell from endoplasmic reticulum stress and preserves oligodendrocytes and myelin during inflammation

First, mild endoplasmic reticulum stress and impaired calcium release seriously disturbed mitochondrial dynamics, thus providing an explanation as to why alterations in the endoplasmic reticulum could lead to impaired mitochondrial dynamics.

Based on the study of the RB51 - macrophage interaction model, endoplasmic reticulum stress activates the inflammasome via NLRP3 - and caspase -2-driven mitochondrial damage (Bronner et al, 2015).

Cannabinoids Induce Apoptosis of Pancreatic Tumor Cells via Endoplasmic Reticulum Stress — Related Genes

The unfolded protein response is partially activated in PEL, but is fully activated in plasma cell tumors, linking endoplasmic reticulum stress to plasma cell development through XBP - 1.

Endoplasmic reticulum stress is triggered not only by protein - folding problems, but also by fatty acids, explained Acosta - Alvear.

In particular, neurons lacking a functional TSC protein complex are more vulnerable to endoplasmic reticulum stress - induced cell death.

In fact, genetic and pharmacological targeting of the IRE - 1 / XBP - 1 pathway of the endoplasmic reticulum stress response, which is critical for antibody production, results in decreased numbers and reduced functions of MDSCs.

Krishnan, N. and Fu, C. and Pappin, D. J. and Tonks, N. K. (2011) H2S - induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response.

Mu Y - ping, Ogawa T, Kawada N. Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine - choline - deficient diet.

An alternate mechanism through which alcohol may limit rates of protein synthesis is endoplasmic reticulum stress and the resultant unfolded protein response.