Sentences with word «endosomal»

The Cdc42 guanine nucleotide exchange factor FGD6 coordinates cell polarity and endosomal membrane recycling in osteoclasts.

We also investigate the mechanisms that in dendritic cells allow for early endosomal escape of antigens leading to subsequent crosspresentation to CD8 + cytotoxic T lymphocytes.

Maike Gravert (Walch - Solimena, MPG)-- «Novel regulators of trafficking in the yeast Golgi - endosomal system» (2006)

Rao and her team hope that pinpointing the importance of this trafficking mechanism in autism spectrum disorders may lead to the development of new drugs for autism that alter endosomal pH. As the use of genomic data becomes increasingly commonplace in the future, the step-wise strategy devised by her team can be used to screen gene variants and identify at - risk patients, she says.

Transport and sorting of proteins and lipids along the endocytic pathway to the lysosome - like vacuole relies on a process called endosomal maturation, where early endosomes change surface composition and morphology before finally fusing with the vacuole.

Retromer binds the late endosomal Rab Ypt7 (blue) and recycles sorting receptors to the Golgi apparatus (green arrows).

We identified interactions between the TGN - localized putative t - SNAREs syntaxin 6, syntaxin 16, and Vti1a, and two early / recycling endosomal v - SNAREs, VAMP3 / cellubrevin, and VAMP4.

The current focus of the research team is to identify new endosomal function inhibitors that are more efficient and more specifically focused on the P45 - IKKα enzyme.

In the study published in the journal Science Signaling, the team led by LLuís Espinosa, investigator of IMIM's research group into stem cells and cancer, have shown that inhibition of endosomal activity is a potential therapeutic strategy for the treatment of cancers with the BRAF mutated gene.

The experiments have shown that the inhibition of endosomal acidification prevents the activation of P45 - IKKα and specifically inhibits the growth of cancer cells with mutant BRAF, both in vitro and in vivo.

Ebola virus requires endosomal two - pore calcium channels to enter host cells.

Ostrowski believes that these results open a path to investigate whether manipulating endosomal traffic could be a new target for anti-HIV-1 therapies.

This paper shows the importance of endosomal MyD88 — IRF7 signalling for robust induction of type I IFN genes in pDCs.

Roberto Villasenor (Zerial, MPG)-- «Regulation of signal transduction by endosomal EGFR distribution» (2012)

These experimental data establish the retromer complex as a key spatiotemporal regulator of IFNAR endosomal sorting and a new factor in type - I IFN - induced JAK / STAT signalling and gene transcription.

Endosomal TLRs have a poor intrinsic ability to discriminate between host - and pathogen - derived ligands and are therefore tightly regulated all along their intracellular trafficking.

A fluorochrome - modified DNA complement to the aptamer was synthesized for co-localization of aptamers and QDs, proving effective endosomal escape for both components.

A defective endosomal — lysosomal autophagy pathway (due to either a primary defect in this pathway or dysfunctional mitochondria) could be the common denominator in various forms of ALS.

At this stage, Ebola virus, enveloped in its own membrane, fuses with the cell's endosomal compartment membrane to release the virus» genes into the cell's inner workings.

Lars Demmel (Walch - Solimena, MPG)-- «Unraveling phosphatidylinositol 4 - kinase function in the yeast Golgi - endosomal system» (2005)

Furthermore, the project will analyze the dynamics of these complexes between membrane and cytosol, the dynamics of their assembly and disassembly on endosomal and vacuolar subcompartments, and their connection to trafficking pathways like the AP - 3 pathway.

After finally receiving Mirkin's thin - optical microscopy data by air mail, Lévy and Mason re-analyzed it and determined the absence of any evidence for endosomal escape, while all Sticky - Flare particles appeared to be localized exclusively inside vesicular membrane compartments, i.e., endosomes (Mason & Levy, bioRxiv 2015).

Current model of endosomal maturation and cargo sorting at the endosome - vacuole interface.

Inhibition of Vps34 activity will affect both autophagy and endosomal trafficking.

«We show that these endosomal inhibitors, currently used in, for example, the prevention and treatment of malaria can be used to prevent metastasis of colorectal cancer, without increasing the toxicity of standard treatments.

This endosomal pathway normally breaks things down to absorb and recycle their components, but Ebola virus hijacks the pathway's functions to infiltrate cells.

This down - regulation was achieved by a heterologous, protein synthesis - dependent activation of the endosomal pathway, which leads to internalization and apparent degradation of apCAM.

The researchers determined that Rab27a boosted PIP2 production at the plasma membrane by controlling the endosomal delivery of an enzyme that is necessary for production of the phospholipid to the cell periphery.

The endosomal phenotype in Down syndrome.

Within this project, we will analyze the activation and turn - over of the endosomal Rab5 (in yeast Vps21) and Rab7 GTPases (in yeast Ypt7), the interplay of these Rabs with the CORVET and HOPS tethering complexes, and the crosstalk with retromer and ESCRT complexes on endosomal microcompartments during their maturation.

Gilleron, J., Querbes, W., Zeigerer, A., Borodovsky, A., Marsico, G., Schubert, U., Manygoats, K., Seifert, S., Andree, C., Stöter, M., Hepstain - Barash, H., Zhang, L., Koteliansky, V., Fitzgerald, K., Fava, E., Bickle, M., Kalaidzidis, Y., Akinc, A., Maier, M., and Zerial, M. Image - based analysis of lipid nanoparticle - mediated siRNA delivery, intracellular trafficking and endosomal escape.

Image - based analysis of lipid nanoparticle - mediated siRNA delivery, intracellular trafficking and endosomal escape.