Sentences with word «endosome»
An endosome is a small structure inside cells that helps to transport and sort various molecules. It acts like a package delivery center, receiving molecules from outside the cell and sending them to different parts within the cell. Full definition
Akhila Chandrashaker (Zerial, MPG)-- «Systems analysis of early endosome motility through identification of molecular motors» (2010)
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Brunetti, C. R., Dingwell, K. S., Wale, C., Graham, F. L. & Johnson, D. C. Herpes simplex virus gD and virions accumulate in endosomes by mannose 6 - phosphate - dependent and - independent mechanisms.
Also, with some nanoparticles much of the material ends up trapped in protective sacs called endosomes inside the cell, and there can be potential toxic side effects.
Structural capsid proteins with three variants: VP1, VP2, and VP3; VP1 possesses phospholipase A2 activity, which is likely necessary to release the AAV particles from late endosomes.
Morrow discussed these current projects on mice with SLC9A6 mutations, including a study that demonstrates increased endosome acidity in mutant neurons [3].
Chao also showed that excess choline inhibited endocytosis, mimicking the effects of CTL1 loss and suggesting that a critical CTL1 function is to sequester choline into endosomes.
We have identified and characterized its effector proteins, and reconstituted them in synthetic endosomes capable of efficient membrane fusion, comparable to the purified organelles.
If it works at ph 5 - 5.5 the reaction is likely happening inside endosomes inside of the cell where the ph is supposed to be in that range.
Sebastian Höpfner (Zerial, MPG)-- «Modulation of cargo transport and sorting through endosome motility and positioning» (2005)
«We want to study what endosome membrane mechanisms block intracellular traffic and hold cholesterol and their negative consequences for our health,» concludes Carles Enrich.
Our studies on the molecular mechanisms of endocytosis led to the discovery that the small GTPase Rab5 is a master regulator of early endosome biogenesis.
Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations.
Polarized endosome dynamics by spindle asymmetry during asymmetric cell division.
They found that the mutant mice had significantly higher endosome acidity.
In this context, we have identified microcompartmentation of signaling complexes in the plasma membrane and in endosomes as important determinants for receptor dynamics and signaling activity.
However, FPs have usage limitations for imaging in low pH environments, such as in acidic organelles, including endosomes, lysosomes, and plant vacuoles.
The ECO is taken up by the cell through endocytosis but the nanoparticles escape endosomes and release the RPE 65 DNA into the nucleus.
In fact, we found the inhibition of acidification of endosomes enhances the effect of conventional chemotherapy in mice, «says Dr. Lluís Espinosa.
They suggest that keeping choline levels low outside endosomes promotes the activity of an enzyme, phospholipase D, that cleaves multiple lipids and, in so doing, has a direct effect on vesicle lipid composition and thus destination.
Because endosomes are the vehicles that deliver cargo essential for communication between brain cells, changing their pH alters traffic to and from the cell surface, which could affect learning and memory, Rao says.
Transport and sorting of proteins and lipids along the endocytic pathway to the lysosome - like vacuole relies on a process called endosomal maturation, where early endosomes change surface composition and morphology before finally fusing with the vacuole.
Exosomes are small endosome derived lipid nanoparticles actively secreted by exocytosis in most living cells
We use the synthetic endosomes made of artificial vesicles and purified recombinant proteins to mechanistically dissect the contribution of each factor to membrane tethering and fusion.
Because certain cell secretion pathways have been suggested to be required for this process, University of Buenos Aires researcher Matías Ostrowski and colleagues investigated whether a role might be played by Rab27a, a protein that guides delivery of membrane - bound compartments called endosomes to the plasma membrane.
Compared with a control T cell (left), loss of Rab27a (right) blocks the delivery of late endosomes (red) to the plasma membrane, inhibiting the recruitment of Gag (green) to HIV - 1 assembly sites.