Sentences with phrase «endosome acidity»

They found that the mutant mice had significantly higher endosome acidity.

The mutant mice with the higher endosome acidity also had more degradation of a receptor protein, called TrkB, that responds a neurotrophic factor called BDNF.

Not exact matches

Using lab - grown mouse astrocytes with variant forms of NHE9, the researchers found a change in the pH (acidity) inside cellular compartments called endosomes, which in turn altered the ability of cells to take up glutamate.

Sometimes acidity in the endosome can activate protein - degrading enzymes called proteases.

In their experiments the researchers measured acidity in the endosomes of brain cells of normal mice and in mice with mutations in the NHE6 gene.