«Our findings show for the first time that (the enzyme) regulates endothelial filopodia formation and, most importantly,
endothelial cell migration by rearranging the cells» phospholipid composition,» the authors report.
Abnormal
endothelial cell migration is seen in various diseases, including rheumatoid arthritis, cancer and macular degeneration.
Researchers suspect that manipulation of vascular
endothelial cell migration could be a useful therapeutic approach for those and other conditions.
Figure 6 shows the effects of 75 µM kahweol on
endothelial cell migration, as determined by the «wound healing» assay, after 8 and 24 h of treatment.
Expression of angiopoietin - 1 in hypoxic pericytes: regulation by hypoxia - inducible factor - 2alpha and participation in
endothelial cell migration and tube formation.
Not exact matches
Like a free pass, its presence on the surface of lymphoma
cells facilitates their
migration through the vessel walls between adjacent
endothelial cells.
It both promotes angiogenesis within the tumor and increased the
migration of
endothelial cells, which form the inner lining of blood vessels.
Activation of
endothelial cells elicits a complex series of responses that include the elaboration of proteolytic enzymes,
migration, and proliferation.
MicroRNA - 195 regulates proliferation,
migration, angiogenesis and autophagy of
endothelial progenitor
cells by targeting GABARAPL1.
MicroRNA - 24 inhibits the proliferation and
migration of
endothelial cells in patients with atherosclerosis by targeting importin - a3 and regulating inflammatory responses.
Release of cytochrome c, Bax
migration, Bid cleavage, and activation of caspases 2, 3, 6, 7, 8, and 9 during
endothelial cell apoptosis.
Endothelial cell - derived GABA signaling modulates neuronal migration and postnatal behavior Li S, Kumar T P, Joshee S, Kirschstein T, Subburaju S, Khalili JS, Kloepper J, Du C, Elkhal A, Szabó G, Jain RK, Köhling R, Vasudevan A. Cell Resea
cell - derived GABA signaling modulates neuronal
migration and postnatal behavior Li S, Kumar T P, Joshee S, Kirschstein T, Subburaju S, Khalili JS, Kloepper J, Du C, Elkhal A, Szabó G, Jain RK, Köhling R, Vasudevan A.
Cell Resea
Cell Research.
Mechanotransduction The effects of extracellular matrix stiffening on
endothelial cell health Cynthia Reinhart - King, Cornell University The effects of membrane cholesterol and extracellular matrix elasticity on vascular smooth muscle
cell mechanics and
migration Zhongkui Hong, University of South Dakota
Research Interests: angiogenesis; atherosclerosis;
cell migration;
endothelial cells; iron metabolism; macrophages; translational control
They include its effects on
endothelial cell «differentiation» to yield tubular - like structures,
endothelial and tumor
cell proliferation, apoptosis, and
migration, as well as its effects on extracellular matrix remodelling enzyme activities of matrix metalloproteinase - 2 (MMP - 2) and urokinase - type plasminogen activator (uPA).
«The present study fills a gap in the literature by showing the relationship between the fatty acid metabolism and the
migration of
endothelial cells.»
We show for the first time that kahweol is an anti-angiogenic compound with inhibitory effects in two in vivo and one ex vivo angiogenesis models, with effects on specific steps of the angiogenic process:
endothelial cell proliferation,
migration, invasion and tube formation on Matrigel.
Endothelial cell - derived GABA signaling modulates neuronal
migration and postnatal...