Sentences with phrase «endothelial cells»

MicroRNA - 24 inhibits the proliferation and migration of endothelial cells in patients with atherosclerosis by targeting importin - a3 and regulating inflammatory responses.

To do that, they deleted the gene for SIRT1, which encodes the major mammalian sirtuin, in endothelial cells of mice.

Tissue - specific microvascular endothelial cell lines from H - 2K (b)- tsA58 mice for studies of angiogenesis and metastasis

Modulation of T cell and B cell interactions with vascular endothelial cells by antibodies, complement, and platelets

Luster's team hopes to further investigate the characteristics of joints that underlie the critical role of C5a in initiating type III hypersensitivity and whether specific molecules expressed on endothelial cells lining joints play a role in transporting C5a and chemokines from the joint space into adjacent blood vessels.

In the chamber, tubes about the thickness of a human hair were lined with endothelial cells as in natural blood vessels.

These cells could be expanded for at least 20 passages (2 ∧ 20 or at least a million-fold expansion) and differentiated into endothelial cells without any significant change in their morphology (Figure S4).

One of the primary objectives of this study was to establish a protocol to facilitate the identification and selection of microvascular endothelial cells from primary organ cultures with a high degree of precision.

Expansion and maintenance of human embryonic stem cell - derived endothelial cells by TGFbeta inhibition is Id1 dependent.

It also helped protect against oxidative damage that leads to brain cell death, and reduced injury to brain endothelial cells in mice with high - fat diets.

Intracellular uptake of macromolecules by brain lymphatic endothelial cells during embryonic development Stefan Schulte - Merker, Westfälische Wilhelms - Universität Münster

«Specifically, the protein expression responsible for endothelial cell degeneration and tight junction damage we identified in this study needs to be confirmed through further tests.

In addition, when these transcription factors lose their function, terminal differentiation into the vascular endothelium (completion of differentiation) is completely suppressed, and genes that are key to differentiation into vascular endothelial cells as well as transcription factors that maintain the undifferentiated state are adversely induced.

Researchers suspect that manipulation of vascular endothelial cell migration could be a useful therapeutic approach for those and other conditions.

Many other natural anti-angiogenic compounds inhibit endothelial cell proliferation [9], [10], [24], [25].

A specific lung - targeting molecule is attached to the carrier's surface and the steriod, dexamethasone, an anti-inflammatory, is loaded into the nanogel, which then binds to lung endothelial cells lining the inside wall of the blood vessels where it rapidly delivers the drug.

To study the molecular mechanisms controlling endothelial cell functions in order to devise valid and better tolerated anti-angiogenic therapy.

Corrected - iPSCs were induced to differentiate into mature endothelial cells which expressed the F8 gene.

A research team led by Robert Fürst of Goethe University found that, in fact, ACC regulates endothelial cell migration.

Amongst these were genes that were lost when endothelial cells were removed from the body and cultured in the laboratory, which potentially explains the previous failure to identify them.

Says Deosarkar, «In this study, we have developed a first realistic pediatric BBB model (B3C) using RBECs from rat pups and human endothelial cells which could serve as an in vitro model system for studying BBB function in pediatric neurological diseases as well as for testing novel therapies for these diseases.»

Differentiated endothelial cells of at 8 days of differentiation show typical cobblestone morphology (B).

Synthetic heparan sulfate oligosaccharides inhibit endothelial cell functions essential for angiogenesis.

Blood vessel endothelial cells act as «gatekeepers», the researchers write in their study published in the journal Scientific Reports.

Microvascular endothelial cells play a critical role in tumor progression and metastasis by forming capillary networks that encourage tumor growth and by promoting the attachment of circulating tumor cells to the vascular wall of distant tissues.

Organ - on - a-chip technology may in part overcome this limitation, as exemplified by the «breathing» lung - on - a-chip that recapitulates the alveolar - capillary interface by co-culturing human alveolar epithelial cells and capillary endothelial cells on opposite sides of a flexible, porous, ECM - coated membrane.

First, they used single - cell RNA sequencing to identify the signaling pathways critical for arterial endothelial cell differentiation.

Yet, more recent discoveries suggest a much more active role of endothelial cells during tumor growth than has been anticipated so far.

In human endothelial cell monolayers in culture, NS1 from any of the four DENV serotypes triggered endothelial barrier permeability.

Endothelial cell activation, vascular smooth muscle dysfunction, oxidative stress, and inflammation, mechanisms which underlie heart disease, diabetes, and hypertension, are all variables which can precipitate or perpetuate immune imbalances in autoimmune disease.

The Weill Cornell researchers» process was more direct: Four transcription factors prompted adult mouse endothelial cells, which line the inside of blood vessels, to turn into HSCs.

This showed leukocytes crossing between the blood - nerve barrier endothelial cells without gaps in the barrier or change in how the barrier is structured.

Ubil found that p53 was «turned on» or overexpressed in the fibroblasts after heart injury and this seemed to regulate fibroblasts becoming endothelial cells.

In vitro, endothelial cells plated on Matrigel align themselves forming cords (Figure 5, C −, negative controls).

Using their nuclei to exert force, they insert themselves between — as well as into — the cells (called endothelial cells) in the vessel walls.