Endothelial cells are special cells that line the inside of our blood vessels, like a layer of skin or fabric. They help regulate the flow of blood, protect the vessel walls, and promote the growth of new blood vessels when needed.
Full definition
MicroRNA - 24 inhibits the proliferation and migration
of endothelial cells in patients with atherosclerosis by targeting importin - a3 and regulating inflammatory responses.
To do that, they deleted the gene for SIRT1, which encodes the major mammalian sirtuin,
in endothelial cells of mice.
Tissue - specific microvascular
endothelial cell lines from H - 2K (b)- tsA58 mice for studies of angiogenesis and metastasis
Luster's team hopes to further investigate the characteristics of joints that underlie the critical role of C5a in initiating type III hypersensitivity and whether specific molecules expressed
on endothelial cells lining joints play a role in transporting C5a and chemokines from the joint space into adjacent blood vessels.
In the chamber, tubes about the thickness of a human hair were lined
with endothelial cells as in natural blood vessels.
These cells could be expanded for at least 20 passages (2 ∧ 20 or at least a million-fold expansion) and differentiated
into endothelial cells without any significant change in their morphology (Figure S4).
One of the primary objectives of this study was to establish a protocol to facilitate the identification and selection of
microvascular endothelial cells from primary organ cultures with a high degree of precision.
It also helped protect against oxidative damage that leads to brain cell death, and reduced injury to
brain endothelial cells in mice with high - fat diets.
Intracellular uptake of macromolecules by brain
lymphatic endothelial cells during embryonic development Stefan Schulte - Merker, Westfälische Wilhelms - Universität Münster
«Specifically, the protein expression responsible
for endothelial cell degeneration and tight junction damage we identified in this study needs to be confirmed through further tests.
In addition, when these transcription factors lose their function, terminal differentiation into the vascular endothelium (completion of differentiation) is completely suppressed, and genes that are key to differentiation into vascular
endothelial cells as well as transcription factors that maintain the undifferentiated state are adversely induced.
Researchers suspect that manipulation of vascular
endothelial cell migration could be a useful therapeutic approach for those and other conditions.
A specific lung - targeting molecule is attached to the carrier's surface and the steriod, dexamethasone, an anti-inflammatory, is loaded into the nanogel, which then binds to
lung endothelial cells lining the inside wall of the blood vessels where it rapidly delivers the drug.
To study the molecular mechanisms controlling
endothelial cell functions in order to devise valid and better tolerated anti-angiogenic therapy.
Amongst these were genes that were lost
when endothelial cells were removed from the body and cultured in the laboratory, which potentially explains the previous failure to identify them.
Says Deosarkar, «In this study, we have developed a first realistic pediatric BBB model (B3C) using RBECs from rat pups and human
endothelial cells which could serve as an in vitro model system for studying BBB function in pediatric neurological diseases as well as for testing novel therapies for these diseases.»
Blood
vessel endothelial cells act as «gatekeepers», the researchers write in their study published in the journal Scientific Reports.
Microvascular
endothelial cells play a critical role in tumor progression and metastasis by forming capillary networks that encourage tumor growth and by promoting the attachment of circulating tumor cells to the vascular wall of distant tissues.
Organ - on - a-chip technology may in part overcome this limitation, as exemplified by the «breathing» lung - on - a-chip that recapitulates the alveolar - capillary interface by co-culturing human alveolar epithelial cells and
capillary endothelial cells on opposite sides of a flexible, porous, ECM - coated membrane.
First, they used single - cell RNA sequencing to identify the signaling pathways critical for
arterial endothelial cell differentiation.
Yet, more recent discoveries suggest a much more active role of
endothelial cells during tumor growth than has been anticipated so far.
Endothelial cell activation, vascular smooth muscle dysfunction, oxidative stress, and inflammation, mechanisms which underlie heart disease, diabetes, and hypertension, are all variables which can precipitate or perpetuate immune imbalances in autoimmune disease.
The Weill Cornell researchers» process was more direct: Four transcription factors prompted adult
mouse endothelial cells, which line the inside of blood vessels, to turn into HSCs.
This showed leukocytes crossing between the blood - nerve
barrier endothelial cells without gaps in the barrier or change in how the barrier is structured.
Ubil found that p53 was «turned on» or overexpressed in the fibroblasts after heart injury and this seemed to regulate fibroblasts
becoming endothelial cells.
Using their nuclei to exert force, they insert themselves between — as well as into — the cells (
called endothelial cells) in the vessel walls.
Phrases with «endothelial cells»