Sentences with phrase «endothelial cells formed»

To determine whether endothelial cells — the cells that line the interior surface of blood vessels — directly influence breast cancer cell growth, they then created unique organotypic models of lung and bone marrow microvascular niches, in which endothelial cells formed blood vessel - like structures in culture as they would in the original organ.

Endothelial cells form the innermost layer of the blood vessels - the endothelium - and have the function of containing blood inside the vessels while allowing the passage of nutrients to tissues.

These malignant tumors were formed by poorly delineated vascular channels lined by pleomorphic endothelial cells forming solid areas and with frequent mitotic figures.

Not exact matches

«Yet after AA147 treatment, around 70 percent of the culture turned into endothelial cells that were able to form blood vessels.

Epithelial cells form tissue layers that cover our skin and the inner surfaces of most of our internal organs, while endothelial cells line the adjacent blood - transporting vessels and capillaries that support their functions.

A critical discovery in this research was finding that the novel progenitor has a receptor protein on its cell surface called KDR, or vascular endothelial growth factor receptor 2, which until now, was thought to be restricted to endothelial cells that form vessels, the progenitors for endothelial cells and the progenitors blood cells.

Using nanoparticles designed and screened for endothelial delivery of short strands of RNA called siRNA, the researchers were able to target RNAi to endothelial cells, which form the linings of most organs.

Within the blood vessels of the brain, endothelial cells and other adjacent cells form a tight barrier that helps to prevent toxins and microbes from entering the brain.

We found a drug that could push this process forward, making even more endothelial cells that help form blood vessels.

Professor Takao Hamakubo's group at the Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), have shown that PTX3 forms strong bonds with histones and partially unfolds, leading to a disordered coaggregation of histone and PTX3 and protecting human endothelial cells from damage.

It both promotes angiogenesis within the tumor and increased the migration of endothelial cells, which form the inner lining of blood vessels.

Due to the lack of oxygen in the cancer cells, VEGF - A (Vascular Endothelial Growth Factor) is formed and this promotes the formation of new blood vessels to supply the tumor.

The transplanted stem cells had differentiated into endothelial cells — which form the inner lining of a blood vessel, providing a barrier between blood and spinal cord tissue — and attached to capillaries in the spinal cord.

It took advantage of the brain's own mechanism for getting a necessary nutrient, iron, across the lining of endothelial cells that form the blood - brain barrier.

Researchers knew at the time that tumors can induce normal endothelial cells to form new blood vessels, a process called angiogenesis.

The ability of the endothelial cells to form capillary - like structures was assessed by placing them on the solubilized basement membrane preparation Matrigel (Becton Dickinson, San Jose, CA), according to the manufacturer's instructions.

Peter Carmeliet and his team demonstrated that endothelial cells can be paralyzed by blocking glycolysis and consequently stop to form blood vessels.

Endothelial cells need nutrients and energy for growth and if you take away their energy, you can prevent them from forming new blood vessels.»

Neutrophils recruit and activate Human Endothelial Colony Forming Cells at the site of vessel injury via PSGL - 1 and L - Selectin.

Priming of endothelial colony - forming cells in a mesenchymal niche improves engraftment and vasculogenic potential by initiating mesenchymal transition orchestrated by NOTCH signaling, FASEB Journal, 31 (2), 610 - 624 doi: 10.1096 / fj.201600.

The vessel formed on the chip includes a channel lined by human endothelial cells and perfused with human whole blood.

The SPG cell layer, which is adjacent to the neurons of the brain, forms septate junctions, which function as a barrier to separate the humoral space and the brain, analogously to the mammalian tight junctions formed between endothelial cells.

By culturing RBECs and human endothelial cells under flow conditions, the researchers found that cell - cell junctions they formed accurately mimicked endothelial barrier formation in the brain.

In vitro, endothelial cells plated on Matrigel align themselves forming cords (Figure 5, C −, negative controls).

In vitro, endothelial cells plated on Matrigel align themselves forming cords, already evident a few hours after plating.

The iPS cells are cultured on the opposite side of the membrane in the other channel that represents the glomerulus» urinary compartment, where they are induced to form a layer of mature podocytes that extend long cellular processes through the pores in the membrane and contact the underlying endothelial cells.

Tube - forming ability of purified CD31 + endothelial cells derived from induced pluripotent stem cells after VEGF treatment.

Elevated plasma concentrations of soluble forms of endothelial adhesion molecules, released from shedding or proteolytic cleavage from the endothelial cell surface, are considered useful indicators of endothelial dysfunction and activation (20, 25).

A damaged endothelial cell wall means low performance during physical activity as well as an increased risk in heart attack since a healthy endothelial cell wall does not allow arterial blockages to form.

The blood brain barrier (BBB) is a physical barrier formed by the arrangement of endothelial cells and tight junctions that line the capillaries which supply blood to the brain.

The endothelial cells work to form new capillaries and help produce granulation tissue.