Sentences with phrase «endothelial growth factor a»

Other progress against the wet form of the disease has come through the use of drugs that target vascular endothelial growth factor.

The list includes platelet - derived growth factors (PDGF), ß - thromboglobulin, fibroblast growth factor, insulin - like growth factor 1, epidermal growth factor, and vascular endothelial growth factor.

Vascular endothelial growth factor concentrations in body cavity effusions in dogs.

Plasma vascular endothelial growth factor (VEGF) concentrations in healthy dogs and dogs with hemangiosarcoma.

In this proposal we set out to utilize our canine - derived scFv phage display platform technology to isolate canine antibody fragments that bind and neutralize Vascular Endothelial Growth Factor (VEGF).

The use of targeting antibodies against vascular endothelial growth factor (VEGF), a protein that promotes tumor growth and spread, plus chemotherapy has prolonged disease free survival in several different tumor types in man.

One of these growth factors is vascular endothelial growth factor - A or VEGF, which acts by binding specific receptors on the hemangiosarcoma cells.

Exercise training leads to the formation of new capillaries in a process called angiogenesis, mediated through the vascular endothelial growth factor (VEGF) signaling pathway (Gavin, 2009).

One major internal contributor to cancer is called «vascular endothelial growth factor,» or VEGF.

Researchers report that curcumin reduces all pro-inflammatory molecules in cartilage cells and in membranes that line the joints, among them tumor necrosis factor — which destroys joint cartilage — and vascular endothelial growth factor, which promotes excessive growth of blood vessels in inflamed joints.

At the same time, the protein Vascular Endothelial Growth Factor (VEGF) stimulates blood supply for the damaged tissue, Fibroblast Growth Factor - 2 (FGF - 2) stimulates the damaged cells to grow and reproduce themselves, Transforming Growth Factor - beta (TGF - beta) stimulates cartilage to grow, and Stem Cell Factor (SCF) stimulates your native inactive stem cells to become activated and assist in the repair of the damaged tissue.

[6] Another natural isoflavinoid, 4 - O - methyl alpinumisoflavone, isolated from the tropical rainforest tree, Lonchocarpus glabrescens, could inhibit HIF - 1 activation and hypoxic induction of HIF - 1 target genes (CDKN1A, GLUT - 1, and vascular endothelial growth factor (VEGF)-RRB-.

«Flavonoids and Vitamin E Reduce the Release of the Angiogenic Peptide Vascular Endothelial Growth Factor from Human Tumor Cells».

-- Naringin is an inhibitor of vascular endothelial growth factor (VEGF) release, which causes angiogenesis (formation of new blood vessels)(4).

Reishi mushroom contains special polysaccharides called beta - glucans said to fight cancer cells by suppressing endothelial growth factor, support the immune system, and enhance cytotoxic receptors (NKG2D / NCR) killer cells.

One class of drugs, called vascular endothelial growth factor inhibitors, for example, is designed to thwart the growth of abnormal blood vessels in the eye.

In 1996, for instance, Semenza demonstrated that HIF - 1 activates the gene for a key participant in blood - vessel formation, vascular endothelial growth factor (VEGF).

Adults with advanced renal cell carcinoma after targeted therapy against vascular endothelial growth factor (VEGF)

Furthermore, ASCs secreted high levels of vascular endothelial growth factor (VEGF) into the wound site, thereby promoting accelerated angiogenesis and encouraging higher levels of wound healing.

Under hypoxic conditions activates the transcription of over 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia.

The drug, marketed as Lucentis, targets a molecule called vascular endothelial growth factor (VEGF), a key player in the growth of blood vessels.

The researchers found that, when stimulated by insulin, diabetic fibroblasts produced less of the VEGF (vascular endothelial growth factor) signaling protein, a key player in boosting the growth of blood vessel cells, than normal fibroblasts did.

Vascular endothelial growth factor receptor, also called VEGFR, is a biomarker found in certain patients with lung cancer.

However, recent small short - term studies have revealed the visual benefits of eye injections of medications that block a chemical signal that stimulates blood vessel growth, known as vascular endothelial growth factor (VEGF).

From these cell based and clinical studies, we have developed important mechanistic ideas such as activation of protein kinase C, the role of vascular endothelial growth factor (VEGF) and selective insulin resistance as some of the basic mechanisms for the pathogenesis of diabetic microvascular and cardiovascular diseases which are now widely studied by multiple laboratories.

Vascular endothelial growth factor (VEGF) expressed by neural progenitor cells (NPCs)(cyan) stimulates the growth of blood vessels (red) in the mouse embryonic hindbrain, and provides regulatory factors to promote the self - renewal of neural progenitors.

For the analysis of mRNA levels for asparagine synthetase (ASNS), CHOP (CCAAT / enhancer - binding protein homologous protein), vascular endothelial growth factor (VEGF), glucose transporter 1 (Slc2a1) and monocarboxylate transporter 4 (Slc16a3), RT - PCR as well as qPCR were used.

Other research has shown that oxygen - deprived cells in the retina produce a type of protein called vascular endothelial growth factor (VEGF), which triggers the growth of new blood vessels in the retina.

Vascular endothelial growth factor (VEGF) regulates angiogenesis, yet therapeutic strategies to disrupt VEGF signaling can interfere with physiologic angiogenesis.

Vikas Gulati, MD Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska Funding provided by a grant from The Alcon Foundation Project: Effect of Vascular Endothelial Growth Factor Blockers on Aqueous Humor Dynamics

Previous efforts to treat ischemia by creating new blood vessels have focused on delivering angiogenic growth factors like vascular endothelial growth factor (VEGF) to ischemic sites.

A phase I trial of ramucirumab, a human monoclonal antibody against the vascular endothelial growth factor - 2 (VEGFR - 2) receptor, in children with refractory solid tumors, including CNS tumors -LRB-

A phase I trial of ramucirumab, a human monoclonal antibody against the vascular endothelial growth factor - 2 (VEGFR - 2) receptor, in children with refractory solid tumors, including CNS tumors (NCT02564198).

Interestingly, PDGF - BB overexpression by modified hDPSCs enhanced the recruitment of hDPSCs both in vitro and in vivo via the activation of the phosphatidylinositol 3 kinase (PI3K) / Akt signaling pathway and, in combination with secreted vascular endothelial growth factor (VEGF), enhanced in vitro angiogenesis.

A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer.

Kandel and colleagues at the Pediatric Tumor Biology Laboratory were the first to describe how experimental pediatric tumor growth could be suppressed by blocking a molecule called vascular endothelial growth factor (VEGF) from performing its natural job.

Phase II study of cediranib (AZD 2171), an inhibitor of the vascular endothelial growth factor receptor, for second - line therapy of small cell lung cancer (NCI # 7097).

Hepatocyte growth factor enhances vascular endothelial growth factor - induced angiogenesis in vitro and in vivo.

Loss of Vascular Endothelial Growth Factor A (VEGFA) Isoforms in the Testes of Male Mice Causes Subfertility, Reduces Sperm Numbers, and Alters Expression of Genes That Regulate Undifferentiated Spermatogonia.

Genetic Reduction of Vascular Endothelial Growth Factor Receptor 2 Rescues Aberrant Angiogenesis Caused by Epsin Deficiency.

Park, Y. S., Kim, N. H. & Jo, I. Hypoxia and vascular endothelial growth factor acutely up - regulate angiopoietin - 1 and Tie2 mRNA in bovine retinal pericytes.

γ - secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor - 1.

A vascular endothelial growth factor - 2 receptor inhibitor enhances anti-tumor immunity through an immune - based mechanism.

In 1989, the gene for vascular endothelial growth factor (VEGF) is identified, leading to the development of anti-angiogenesis treatments including bevacizumab (Avastin) for cancer.

His study highlighted a role for vascular endothelial growth factor (VEGF) in N - methyl - D - aspartate (NMDA) receptor trafficking via the activation of long - term potentiation signaling pathways at the post-synaptic sites (De Rossi et al, 2016).

The pioneering work of Dr. Aiello helped demonstrate the role of vascular endothelial growth factor (VEGF) in diabetic retinopathy and other retinal disorders, as well as the therapeutic potential of VEGF inhibitors in these conditions.

So what happens is the xaliproden works in a different way than a normal anti-vascular endothelial growth factor (VEGF) agent or AREDS formula in clinical trials for dry AMD — it doesn't work in the same way.

Bevacizumab (Avastin ®), which targets vascular endothelial growth factor (VEGF), is FDA - approved for the treatment of ovarian cancer.

Vascular endothelial growth factor signaling is necessary for expansion of medullary microvessels during postnatal kidney development.

Bevacizumab blocks the activity of vascular endothelial growth factor (VEGF), which stimulates angiogenesis.