Malaria parasites grow in red blood cells and stick to
the endothelial lining of blood vessels through a large family of parasite proteins called PfEMP1.
The mediator of this effect is an odorless, colorless gas called nitric oxide, produced by
the endothelial lining of every blood vessel in your body under conditions of health and pleasure, meaning sustainable aerobic exercise.
«Forks Over Knives» is about returning to that level of simplicity in our food consumption ~ ~ raw, whole foods with minimal processing with no animal product and minimal oil — the good doctors have the science behind the destruction of
the endothelial lining of our blood vessels and the development of cancer and vascular disease when these animal products, processed foods and oils are consumed.
While you promote healthy fats for brain, neurological and general health; Dr. Esselstyn suggests that all oils damage
the endothelial lining of our blood vessels... I am interested in adopting your suggestions, and have read «Grain Brain,» but remain a little apprehensive of embracing healthy fats... how would you address Dr. Esselstyn specifically?
Not exact matches
The Weill Cornell researchers» process was more direct: Four transcription factors prompted adult mouse
endothelial cells, which
line the inside
of blood vessels, to turn into HSCs.
In experiments conducted on human lung
endothelial cells and in mice, the researchers showed that NS1 caused permeability
of the endothelium, which
lines the walls
of blood and lymph
vessels.
Epithelial cells form tissue layers that cover our skin and the inner surfaces
of most
of our internal organs, while
endothelial cells
line the adjacent
blood - transporting
vessels and capillaries that support their functions.
In their latest study, Guarente and his colleagues decided to explore the role
of sirtuins in
endothelial cells, which
line the inside
of blood vessels.
Luster's team hopes to further investigate the characteristics
of joints that underlie the critical role
of C5a in initiating type III hypersensitivity and whether specific molecules expressed on
endothelial cells
lining joints play a role in transporting C5a and chemokines from the joint space into adjacent
blood vessels.
Current thinking regarding type III hypersensitivity is that immune cells within tissues sense the presence
of these immune complexes (ICs) through specific receptor molecules and release inflammatory factors called cytokines that activate the
endothelial cells
lining adjacent
blood vessels to promote the recruitment
of neutrophils.
In earlier studies involving animal models and human cancer cell
lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an
endothelial cell (a type
of cell that
lines the
blood vessels), a perivascular macrophage (a type
of immune cell found near
blood vessels), and a tumor cell that produces high levels
of Mena, a protein that enhances a cancer cell's ability to spread.
In the current study, the researchers report that NOTCH1 acts like a sensor on the
endothelial cells — the cells that
line the valve and
vessels — detecting
blood flow outside
of the cell and transmitting information to a network
of genes inside the cell.
The researchers then differentiated the iPS cells into
endothelial cells, which
line the interior
of the heart and
blood vessels, before transplantation.
To determine whether
endothelial cells — the cells that
line the interior surface
of blood vessels — directly influence breast cancer cell growth, they then created unique organotypic models
of lung and bone marrow microvascular niches, in which
endothelial cells formed
blood vessel - like structures in culture as they would in the original organ.
In the chamber, tubes about the thickness
of a human hair were
lined with
endothelial cells as in natural
blood vessels.
Using a powerful imaging technique that allowed the scientists to track the presence and movement
of parasites in living tissues, the researchers found that Toxoplasma infects the brain's
endothelial cells, which
line blood vessels, reproduces inside
of them, and then moves on to invade the central nervous system.
«
Endothelial cells make up the inner
lining of blood vessels,» said William Durante, Ph.D., professor
of medical pharmacology and physiology at the MU School
of Medicine and lead author
of the study.
The study, published in Proceedings
of the National Academy
of Sciences, found that rod - shaped nanoparticles — or nanorods — as opposed to spherical nanoparticles, appear to adhere more effectively to the surface
of endothelial cells that
line the inside
of blood vessels.
It both promotes angiogenesis within the tumor and increased the migration
of endothelial cells, which form the inner
lining of blood vessels.
«Up to now, the Tie2 receptor has only been known in
endothelial cells that
line the inside
of blood vessels,» Milde said.
Instead
of dispensing ink, Organovo's bioprinter uses two robotic tips to deposit globs
of cells — in this case,
endothelial cells that
line blood -
vessel walls, smooth muscle cells that regulate
vessel dilation and contraction, and structural fibroblast cells.
Among other effects, immune cells disrupt the function
of the
endothelial layer, the
lining of the
blood vessels, counteracting «all the good things that the
endothelial cells produce,» says physiologist Brett Mitchell
of Texas A&M College
of Medicine in College Station.
A specific lung - targeting molecule is attached to the carrier's surface and the steriod, dexamethasone, an anti-inflammatory, is loaded into the nanogel, which then binds to lung
endothelial cells
lining the inside wall
of the
blood vessels where it rapidly delivers the drug.
In an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which cells from a human intestinal cell
line originally isolated from a tumor were cultured in one
of two parallel running channels, separated by a porous matrix - coated membrane from human
blood vessel - derived
endothelial cells in the adjacent channel.
That's because experiments conducted on the International Space Station involving cells that
line the inner surfaces
of blood vessels (
endothelial cells) show that microgravity accelerates cardiovascular disease and the biological aging
of these cells.
To study this barrier and determine why a lack
of blood flow causes it to leak, the researchers built a
blood -
vessel - on - a-chip model consisting
of a channel
lined with a layer
of human
endothelial cells surrounded by extracellular matrix within a microfluidic device, which allowed them to easily simulate and control the flow
of blood through a
vessel and evaluate the cells» responses.
The force
of that
blood flow helps keep the cells that
line the
blood vessels, called
endothelial cells, healthy; when
blood flow is disrupted, such as during surgical procedures or a stroke, the
vessels start to leak, which can cause a host
of inflammatory responses that lead to cell damage and disease.
The transplanted stem cells had differentiated into
endothelial cells — which form the inner
lining of a
blood vessel, providing a barrier between
blood and spinal cord tissue — and attached to capillaries in the spinal cord.
This environment includes
endothelial cells (the cells
lining the inside
of blood vessels) and extracellular matrix (ECM) components, which provide structural support and signaling to surrounding cells.
At that key point, Takebe added two more types
of cell known to help to recreate organ - like function in animals:
endothelial cells, which
line blood vessels, taken from an umbilical cord; and mesenchymal cells, which can differentiate into bone, cartilage or fat, taken from bone marrow.
The study focuses on
endothelial cells, the cells
lining the inside
of blood vessels in which atherosclerotic plaques develop.
Endothelial progenitor cells (EPCs) differentiate into the cells that make up the
lining of blood vessels, and so play roles in vasculogenesis and angiogenesis.
With potential therapeutic implications, Stainier and a colleague also recently discovered that
endothelial cells, which
line the
blood vessels, play a critical role in inducing the development, or proper differentiation,
of red
blood cells, the transporters
of oxygen.
Protein nitrotyrosine is a marker for inflammatory or oxidative stress processes (characteristic
of COPD) and may also indicate
endothelial dysfunction (systemic malfunctioning
of the inner
lining of blood vessels), a common cause
of cardiovascular disease.
The most potent
of these, known as effector memory T cells, are activated by a group
of proteins known as human leukocyte antigens (HLAs) on the surface
of endothelial cells
lining the donated organ's
blood vessels.
Endothelial cells
line the inside
of all
blood vessels and regulate inflammation,
blood clotting following injury and
blood pressure levels.
A team at the Harvard John A. Paulson School for Engineering and Applied Sciences (SEAS) and the Wyss Institute for Biologically Inspired Engineering at Harvard University has invented a method for 3D bioprinting thick vascularized tissue constructs composed
of human stem cells, extracellular matrix, and circulatory channels
lined with
endothelial blood vessel cells.
A team led by Young - sup Yoon, MD, PhD developed a new method for generating
endothelial cells, which make up the
lining of blood vessels, from human induced pluripotent stem cells..
Chunhui Xu's lab in the Department
of Pediatrics recently published a paper in Stem Cell Reports on the differentiation
of endothelial cells, which
line and maintain
blood vessels.
Its also possible, experts say, that C enhances the functioning
of endothelial cells (which
line the inside
of all
blood vessels), slowing artery clogging and lowering
blood pressure.
Isoflavones bolster the
blood's nitric oxide levels, improving the
endothelial lining function
of blood vessels.
Researchers report that curcumin reduces all pro-inflammatory molecules in cartilage cells and in membranes that
line the joints, among them tumor necrosis factor — which destroys joint cartilage — and vascular
endothelial growth factor, which promotes excessive growth
of blood vessels in inflamed joints.
Hemangiosarcoma An incurable tumor
of cells that
line blood vessels (
endothelial cells).
Hemangiosarcoma is a cancer
of endothelial cells — the cells that
line blood vessels.
It is an incurable tumor
of cells that
line blood vessels, called vascular
endothelial cells.