In the Collagen Antibody Induced Arthritis (CAIA) model, arthritis is stimulated through the administration of a cocktail of monoclonal antibodies that are directed to conserved auto - antigenic epitopes of collagen type II, followed by
endotoxin challenge.
LPS as 2nd hit: After chronic ethanol feeding, 8 - 10 wk old mice are
challenged with 0.7 μg LPS / g body weight or an equivalent volume of sterile,
endotoxin - free saline (0.09 %).