Sentences with phrase «ends of a broken dna»

Then, they showed that when the cancer cells didn't make enough ATRX, the cells couldn't join together the two ends of a broken DNA strand.

Not exact matches

James Christiansen, professor of biology at Drake University in DesMoines, is studying how telomeres, the simple, non-genetic DNAsequences that sheathe the ends of chromosomes, function in reptiles.Each time a healthy human cell divides, it loses a little bit of thetelomere, until the strands are too short to protect the chromosomes.At that point the DNA in a cell begins to break down, which triggerssenescence and death.

Previous studies have implicated the DNA polymerase θ (Polθ also known as POLQ, encoded by POLQ) in a pathway required for the repair of DNA double - strand breaks, referred to as the error - prone microhomology - mediated end - joining (MMEJ) pathway.

For example, non-homologous end - joining is involved in the development of lymphocytes in resolving recombination intermediates i.e., DNA strand breaks (DSBs) that occur during V (D) J recombination.

(2016) RB localizes to DNA double - strand breaks and promotes DNA end resection and homologous recombination through the recruitment of BRG1.

Zinc finger nucleases [1], [2], transcription activator - like effector nucleases [3], [4] and homing meganucleases [5] have provided powerful tools to induce targeted mutations in the form of small insertions or deletions derived from DNA break repair of nonhomologous end joining (NHEJ) or homologous recombination.

Cells lacking HRR must repair double - strand DNA breaks through more error - prone forms of DNA repair such as nonhomologous end joining.

They protect chromosome ends from being mistaken for broken pieces of DNA that would otherwise be fixed by cellular repair machinery.

This pre-lab activity would allow them to use different «chemical tools» to break down the various parts of the cell and, in the end, identify a list of materials needed to complete the DNA extraction lab.