Porcar's team
engineered gene switches in Escherichia coli to produce proteins that emit different coloured fluorescent light when factors such as heat, acidity and oxygen levels change.
Not exact matches
To determine the effect of mutations that reduce TET2 function in abnormal stem cells, the research team genetically
engineered mice such that the scientists could
switch the TET2
gene on or off.
This type of
switch should also be applicable to other
engineered metabolic pathways because the genetic circuit can be targeted to shut off other
genes.
The researchers
engineered a strain in which a Synechococcus
gene normally turned on during photosynthesis signals its activity by
switching on the
gene for luciferase, an enzyme from another bacterium that drives a light - emitting chemical reaction.
To confirm the links, the group harnessed cutting edge techniques in genetic
engineering and viral
gene delivery to
switch on neurons in the front of healthy mouse brains.
Researchers have developed a set of genetic
switches that can be built into
engineered organisms, to control the function of
genes they need to survive.
A key future experiment will involve attaching a malaria - resistance
gene to the Myd88 code
engineered to get
switched on in the offspring during early development.
With the help of this grant, we are generating mice
engineered to
switch off the APOE
gene only in microglia and performing molecular profiling without having to isolate microglial cells first.
You've just been tasked with discovering which
genes in the human genetic code do what by forcefully genetically
engineering babies to have certain traits defined by which
genes you
switch on.