Sentences with phrase «engineered immune cells»

The goal: To wipe out the patient's existing immune cells, so that the genetically engineered immune cells can do their job with minimal interference.

Properly engineered immune cells could enable scientists to direct highly specific, long - lasting immune response mechanisms against a disease.

A molecule on glioblastoma cells that could be used as a target for genetically engineered immune cells has been identified.

One interesting strategy is the use of engineered immune cells which are designed to specifically target and destroy HIV.

Imagined applications include engineered immune cells that can sense and respond to cancer markers or cellular biosensors that can easily diagnose infectious disease in patient tissue.

In September 2010 Sharp received a single infusion of 20 billion of his genetically engineered immune cells.

The treatment with the engineered immune cells, called CAR - T cell therapy, may work even better if doctors transplant a subset of immune cells known as memory T cells, researchers reported February 14...

«When we exposed a near - infrared laser beam to these animal models injected with both the nanoparticle and the genetically engineered immune cells, this caused calcium channels on the dendritic cells to open and we saw a corresponding increase in the number of T - cells that were activated,» said Han.

To manufacture CAR T cells, scientists extract bone marrow from a patient, introduce genetic instructions for a CAR into the T cells, and then infuse those engineered immune cells back into the person's bloodstream.

The team genetically engineered immune cells so that a calcium gate - controlling protein became light sensitive.

They use a near - infrared laser beam, which can penetrate deep — in this context, deep means a centimeter or two — into the tissue, where a nanoparticle turns the near - infrared light into blue light, and that directs the activity of genetically engineered immune cells.

It plans to use Crispr for engineering immune cells and blood stem cells, and as a research tool for drug discovery.

Researchers used molecular scissors called CRISPR / Cas9 to engineer immune cells that were then injected into a patient with lung cancer, Nature reports.

The proposed clinical trial, in which researchers would use CRISPR to engineer immune cells to fight cancer, won approval from the Recombinant DNA Advisory Committee (RAC) at the U.S. National Institutes of Health, a panel that has traditionally vetted the safety and ethics of gene therapy trials funded by the U.S. government and others.

His laboratory harnesses the tools of synthetic and chemical biology to engineer the immune cell therapies for cancer and autoimmunity of the future.

Considerable success has been achieved in engineering immune cells to evade the suppressive effects of cancer and kill malignant cells.

The awards span the broad mission of the NIH and include groundbreaking research, such as engineering immune cells producing drugs at the site of diseased tissue; developing a sensor to rapidly detect antibiotic resistance of a bacterial infection; understanding how certain parasites evade host detection by continually changing their surface proteins; and developing implants that run off the electricity generated from the motion of a beating the heart.

And doctors at the Great Ormond Street Hospital in London recently reported using a similar gene - editing technique called TALENs, which also recognizes and cuts precise DNA sequences, to engineer immune cells for a therapy that may have cured two infants of leukemia.

Not exact matches

The U.S. Food and Drug Administration approved two personalized treatments that engineer a patient's own immune system to hunt down and kill cancer cells.

An engineered bone that has its own marrow can encourage donor stem cells to produce blood, a feat that could help people with anaemia and rare immune diseases

The treatment, called CAR - T immunotherapy, uses genetically engineered T cells, immune system fighters usually tasked with identifying invaders in the body,...

This study, «Engineered epidermal progenitor cells can correct diet - induced obesity and diabetes,» is the first to show that an engineered skin graft can survive long term in wild - type mice with intact immune systems.

Tissue - engineered livers grown from stem cells, say, could have their genetic code altered so that they would be immune to liver - destroying viruses such as hepatitis C.

However, some mice experienced dangerous levels of brain swelling, a side effect of the immune response triggered by the engineered cells, the researchers said, adding that extreme caution will be needed to introduce the approach in human clinical trials.

For example, immune cells could be engineered to patrol a person's body, recording what they see and reporting back when recaptured.

The JDF Center for Islet Cell Transplantation will fund 32 researchers to focus on four main goals: Reversing the overactive immune response that kills islet cells; finding new sources for islet cell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of transplantatCell Transplantation will fund 32 researchers to focus on four main goals: Reversing the overactive immune response that kills islet cells; finding new sources for islet cell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of transplantatcell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of transplantation.

So far she has treated mice with the engineered cells, which give rise to HIV - resistant immune cells.

This is an illustration of how the engineered protein facilitates destruction of latently HIV - infected immune cells.

In most cases, the animals» immune systems are compromised, or the rodents have been genetically engineered to rapidly spread mutant cells.

IMMUNE ATTACK Doctors can engineer a patient's own immune cells to kill cancer IMMUNE ATTACK Doctors can engineer a patient's own immune cells to kill cancer immune cells to kill cancer cells.

Coussens and her U.C.S.F. colleagues Douglas Hanahan and Zena Werb reported in 1999 that mice engineered with activated cancer genes but without mast cells (another type of innate immune cell) developed premalignant tissue that did not progress to full malignancy.

They found that indeed, they do, and that stimulating these cells led them to kill cells infected with HIV - 1 derived from latently infected cells, both in culture and in mice engineered to have a human immune system.

But rather than delivering the entire gene for the clotting - factor proteins to cells, as most gene therapies do, the researchers used the viruses to engineer immune - regulating B cells to express a fragment of the clotting factor fused to an immune molecule called an immunoglobulin.

The treatment, called CAR - T immunotherapy, uses genetically engineered T cells, immune system fighters usually tasked with identifying invaders in the body, such as bacteria, viruses or foreign cells.

The Stanford researchers, who report their results in the current issue of the Journal of Experimental Medicine, used a clever trick to shut off this damaging immune response: They engineered TH1 cells to produce IL - 4 instead of their normal cytokines.

Now a team of engineers at MIT has developed a new way to deliver such vaccines directly to the lymph nodes, where huge populations of immune cells reside: These vaccines hitch a ride to the lymph nodes by latching on to the protein albumin, found in the bloodstream.

SynNotch engineered T cells are also versatile in that they can either be used drive a potent immune response to cancer or suppress an immune response in an autoimmune setting,» he said.

Using a combination of human or specially engineered mouse cells in vitro and in vivo animal models, study senior investigator Judy Lieberman, MD, PhD; study lead investigator Farokh Dotiwala, PhD, with a team lead by the Brazilian parasitologist Ricardo Gazzinelli, DSc, DVM, found that when an immune killer cell, such as a T - cell or natural killer (NK) cell, encounters a cell infected with any of three intracellular parasites (Trypanosoma cruzi, Toxoplasma gondii or Leishmania major), it releases three proteins that together kill both the parasite and the infected cell:

Recently, scientists have engineered cells from a patient's own immune system to fight blood cancers.

And, in fact, these doctors and researchers are finding incredible success with this strategy; for example, PD - 1 inhibitors remove this «cloak» that cancers use to hide from the immune system, and CAR - T cell therapies use specially engineered T - cells to seek cancer - specific proteins and destroy the cancer cells to which they are attached.

Two types of vaccines were used for the study: one constructed with genetically engineered DNA molecules that teach immune system cells to recognize premalignant cells expressing HPV16 E7 proteins, and one that is a non-infectious, engineered virus that targets and kills precancerous cells marked by HPV16 and HPV18 E6 and E7 proteins.

The researchers are now looking at how ICOS signals can be altered to diminish autoimmune disorders and augmented for more effective vaccine development, and are beginning research on how ICOS signaling may benefit Chimeric Antigen Receptor - T cell (CAR - T) therapies, which involves engineering of patient's own immune cells to recognize and attack their cancers.

If some of those cells could be removed from a person with AIDS, genetically engineered to be resistant, and then returned to the patient, they might spawn an immune system that is completely resistant to the disease.

This approach is also being used to reverse engineer even more complex gut environments by integrating other cell types, such as immune cells, neuronal cells, and commensal microbes into the device.

By engineering red blood cells to have «sticky» proteins on their surface, a team of researchers has given the cells the ability to carry anything from drugs to treat immune disorders or cancer to radioactive molecules used in imaging of blood vessels.

«We are basically educating the immune system with these nanodiscs so that immune cells can attack cancer cells in a personalized manner,» said James Moon, the John Gideon Searle assistant professor of pharmaceutical sciences and biomedical engineering.

For example, scientists could engineer T cells, sentinels of the immune system, with genetic circuits that initiate a response to wipe out tumors when they detect the presence of two or three «biomarkers» produced by cancer cells, Lu says.

The vaccine is unique to the individual participant and is engineered to trigger an immune system response to kill tumor cells that may remain following surgery.

Another possibility is attaching the contrast agent to immune cells engineered to attack a patient's tumor, allowing the cells to be tracked inside the body.

The team engineered their DNA scissors to target a mutation that causes severe combined immune deficiency (SCID), also known as «bubble boy disease,» an often fatal condition that disrupts the ability of immune T cells to fight infections.