Once Katlyn arrived in May 2007, Candotti and his team removed stem cells from her bone marrow and exposed them to
the engineered retrovirus, creating a human - virus hybrid.
One approach, she says, would be to
engineer the retroviruses to produce integrases that resemble those made by Ty3.
Next, the Stanford group plans to
engineer their retroviruses to transfer IL - 4 genes directly into cells in live mice.
Not exact matches
A significant advantage of ZFN gene modification, compared to
retrovirus based approaches, is that only transient transgene expression is required to permanently
engineer an HIV resistant cell.
He delivered active versions of these genes, using
retroviruses engineered for the purpose.