By assessing the survival of the
cells that
engulf the particles and measuring the levels of red or green light that they emitted, the researchers determined which formulation of particles performed best, then tested that formulation in mice with
human brain
cancer derived from their patients.
«Our new approach takes young and aggressive macrophages from the bone marrow of a
human donor and removes a key safeguard that
cancer cells have co-opted to prevent them from being
engulfed,» Alvey said.