Comprehensive knowledge about the evolution of Dengue in response to selection pressure is currently unavailable, but would greatly
enhance vaccine design efforts.
Not exact matches
Instead, the
vaccine is
designed to
enhance natural immunity so the body flushes out the parasite before it gets entrenched.
«Results from a former AIDS
vaccine study have shown that in a worst case scenario, immunization against HIV could
enhance infection,» says Christiane Stahl - Hennig, who
designed the project in cooperation with the former DPZ employee Sieghart Sopper.
His lab has extensive experience evaluating and modulating T cell responses to tumors and viruses, including introducing genes into T cells to impart specificity and modulate function,
designing strategies to overcome tolerance and
enhance in vivo activity, and developing mouse models that more accurately model human immune responses to candidate
vaccines.
Using
enhanced DNA technology, the lab has
designed DNA
vaccines that drive immune responses in prophylactic or therapeutic settings against Human Immunodeficiency Virus (HIV), Dengue (DV), Chikungunya virus (CHIKV), Middle Eastern Respiratory Syndrome (MERS) virus, and Zika Virus (ZV).