Sentences with phrase «enhanced expression levels»
«exerted numerous adverse effects, including reduction in beneficial decal microflora, increased fecal pH, and enhanced expression levels of p - gp»
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4 weeks of moderate exercise further enhanced glycogen levels and normalized MCT2 expression in the hippocampus of type 2 diabetic rats.»
In cell culture, high expression levels of GPR161 induced proliferation of mammary epithelial cells, disrupted the acinar structures formed by these cells, and enhanced their invasive capacity.
According to Dr. Schwarz, «We observed acute proinflammatory changes, namely, leukocytosis, neutrophilia, upregulated levels of IL - 6 in serum, and enhanced messenger RNA expression of IL - 6 and tumor necrosis factor alpha.
Increasing the expression of one of the proteins, SIX3, in the insulin - producing cells isolated from younger donors enhanced their ability to respond efficiently to rising glucose levels.
«The enhancing effect was not seen in a patient tumor sample with a low level of NRP - 1 expression on the vasculature.
The ability to enhance nanoparticle uptake is dependent on the level of expression of a molecule, called NRP - 1, to allow the peptide to bind to the tumor blood vessels.
The addition of IFN - γ was used to enhance the expression of the MHC H - 2Kb class I promoter, which regulates the level of large T antigen protein in ImmortoMouse - derived cells (10).
While expression levels of all marker genes remained almost unchanged in wild - type ACVR1 cultures compared with the empty viral vector, the expression profile induced by caACVR1 Q207D displayed evidence of advanced chondrogenic differentiation as shown by decreased levels of the early differentiation stage marker collagen type II together with enhanced expression of the later - stage markers Ihh and collagen type X. Indian hedgehog has been shown previously to be induced by BMP signaling transmitted via the ACVR1 receptor (9).
Enhanced expression of one of these molecules, CD1d, is coupled to selective induction of invariant natural - killer T cells (iNKT), a subset of T lymphocytes that are present at low levels in lymphocyte populations and whose absence enhances autoimmunity in animal models.
High mRNA expression levels of HNF4α and ASGPR1 are shown in the enhanced hiPS - HEP cells for an extended culture time and are comparable to levels in cryopreserved human primary hepatocytes (hphep cells) that have been grown for only a short time.
Also, by fine tuning expression levels with feedback regulation [34], digital like regulation can be added that enhances sensitivity and provides biological memory.
Additionally, Western blot analysis indicated that the expression level of p21waf1 / cip1 gene was also enhanced by the ectopic expression of DDX3 in HuH - 7, HeLa, and 293T cells (Fig. 2B).
Expression levels of DDX3 mRNA in HCC samples as shown in (B) are classified into unchanged, decreased, and enhanced categories.
The overall score encompass several factors: reproducibility of the antibody staining in different cell lines (and if signal strength correlates with RNA expression levels); assays for enhanced antibody validation by using antibodies binding to different epitopes on the same target protein (independent antibodies), by knockdown / knockout of the target protein (genetic methods) and by matching of the signal with a GFP - tagged protein (recombinant expression); experimental evidence for location described in literature.
We use an ES cell line in which low levels of Hex transcript are visualized based on the expression of the enhanced YFP, Venus coupled to a unique translational amplifier.
Despite this possibility, mevinolin, the active ingredient in red yeast rice, is capable of reducing 7 - dehydrocholesterol levels, 22 and simvistatin (Zocor) not only inhibits the synthesis of mevalonate but also enhances the conversion of 7 - dehydrocholesterol to cholesterol by increasing the expression of 7 - DHCR.23 Simvistatin thereby hits the pool of 7 - dehydrocholesterol with a double - whammy, both decreasing its synthesis and increasing its degradation.
Besides promoting immunogenicity of the thyroglobulin molecule, dietary iodine can enhance levels of reactive oxygen species (ROS), which lead to expression of cell adhesion molecules (ICAM - 1) that are crucial to the early phases of thyroid follicular inflammatory responses (3).
It is likely that insulin levels are going and remaining very low on a very low carbohydrate diet, and that would be a very beneficial effect as it pertains to the genetic expression of enhanced repair and longevity.
Mukherjee A, Malik H, Saha AP, Dubey A, Singhal DK, Boateng S, Saugandhika S, Kumar S, De S, Guha SK, Malakar D. Resveratrol treatment during goat oocytes maturation enhances developmental competence of parthenogenetic and hand - made cloned blastocysts by modulating intracellular glutathione level and embryonic gene expression.