Peg 3
enhances cell reprogramming by acting on cell metabolism.
Not exact matches
The team demonstrated that
cell sex considerably influenced cellular uptake of nanoparticles and found that
cells from men and women responded differently to
reprogramming techniques used to
enhance the ability of the
cells to differentiate into a greater variety of
cell types.
First discovered a series of small molecules and conditions that can replace
reprogramming transcription factors and
enhance reprogramming efficiency in generating iPS
cells from somatic
cells.
Gladstone scientists discovered a way to
enhance the efficiency of stem
cell reprogramming with a gene mutation that causes «stone man syndrome.»
Such performance -
enhancing alterations will include
reprogramming using non-integrating vectors or small molecules, the identification of the specific
cell within the CS populations which provides therapeutic benefit, and the long - term consequences of CS
cell transplantation.
Scientists
enhance efficiency of stem
cell reprogramming with gene mutation that causes «stone man syndrome»
We have shown that cyclic activation of the Wnt / b - catenin signalling pathway
enhances cell - fusion - mediated reprogramming of a variety of somatic cells (Lluis et al., Cell Stem Cell 2008, Marucci et
cell - fusion - mediated
reprogramming of a variety of somatic
cells (Lluis et al.,
Cell Stem Cell 2008, Marucci et
Cell Stem
Cell 2008, Marucci et
Cell 2008, Marucci et al..
Her winning essay in Science, «Hope for the Brokenhearted,» explains how cellular
reprogramming has greatly
enhanced the study of stem
cells and regenerative medicine.
In her own lab, she has discovered barriers to direct
reprogramming that, when broken down,
enhance the conversion of one
cell type to another.
In addition to identifying a
cell population with
enhanced reprogramming efficiency, we also identified an SSEA3 - negative population with either significantly reduced
reprogramming efficiency or no
reprogramming ability.
Structure - based discovery of NANOG variant with
enhanced properties to promote self - renewal and
reprogramming of pluripotent stem
cells.
Reduced expression of Paternally Expressed Gene - 3
enhances somatic
cell reprogramming through mitochondrial activity perturbation, Scientific Reports.
- catenin and Nanog fluctuate synchronously in mouse ESCs and cooperate to
enhance reprogramming of somatic
cells to pluripotency.
Methods to
enhance the
reprogramming efficiency would significantly increase the feasibility of this approach, especially for
cell types which tend to be more difficult to
reprogram, such as the primary adult human fibroblasts used in this study.