Sentences with phrase «enhances production of the cytokines»
LTB4 increases edema and chemotaxis, induces release of lysosomal enzymes, increases reactive oxygen species, and enhances production of the cytokines TNF - α, IL - 1, and IL - 6.»
http://webspace.pugetsound.edu/ Not exact matches
Deletion of DGKζ from T cells results in prolonged TCR signal transduction downstream of DAG, resulting in enhanced activation of Ras, increased effector T cell proliferation, and amplified cytokine production, which leads to increased antitumor activity against s.c. implanted EL4 tumors or murine mesothelioma (12, 16, 17).
He showed that engagement of PD - 1 by PD - L1 or PD - L2 inhibited T cell activation, cytokine production, and cytolytic activity whereas blockade enhanced these activities.
That being said, the production of pro-inflammatory cytokines is associated with insulin resistance, obesity and metabolic syndrome, whereas a higher production of anti-inflammatory cytokines has been shown to improve insulin sensitivity (which helps protect the organism from developing diabetes and cardiovascular diseases), decrease fat storage, enhance muscle regeneration and support longevity.
Probiotic supplementation has been shown to strengthen the activity of many cytokines — increasing interleukin (IL)-1 β and IL - 18 activates IFN - γ production from T, B, and Natural Killer Cells, which enhances phagocytosis (destruction) of pathogens.
Onto some next - level magic — mushrooms have been shown to enhance the body's production of cytokines and increase white blood cell activity, which makes them more aggressive in fighting off infection.
In times of intense physical stress, they help enhance immune activity by promoting the production of cytokines.
Phytochemicals called anthocyanins give the vegetable its color and enhance wound healing by boosting production of cytokines, a type of protein that triggers a protective immune response.
For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.
At the Bundesforschungsanstalt research center in Karlsruhe, Germany, scientists conducting studies on Elderberry showed that elderberry anthocyanins enhanced immune function by boosting the production of cytokines.
Although greater early local production of proinflammatory cytokines at wound sites is beneficial because it is associated with enhanced healing, greater systemic production of proinflammatory cytokines can represent a maladaptive response.24 Both physical and psychological stressors can provoke transient increases in plasma levels of proinflammatory cytokines, particularly IL - 6,25 as can negative emotions like depression and anxiety.26 - 28 More frequent or persistent stress - related changes have broad implications for physical and mental health; sustained elevated levels of proinflammatory cytokines have been linked to a variety of age - related diseases, including cardiovascular disease, osteoporosis, arthritis, type 2 diabetes mellitus, certain cancers, and frailty and functional decline.29 - 31
Thus, a series of studies have shown that marital conflict alters physiological functioning, and hostile behavior, particularly during conflict, markedly enhances adverse physiological changes; moreover, women appear to be more adversely affected than men.5 In this study, we extended this line of research to assess how hostile marital behavior modulated an important health outcome, wound healing, as well as local and systemic proinflammatory cytokine production.
In addition, depression and stress are associated with enhanced production of proinflammatory cytokines that influence a spectrum of conditions associated with aging.