Sentences with phrase «entire gene»

We still don't know enough about how these molecules influence specific genes, entire gene families, or biochemical reaction pathways.

But sometimes mutations arise that disable entire genes from one parent.

Instead of looking for point mutations — changes to part of a gene — they studied whether entire genes were repeated an unusual number of times.

The policy — in the form of first Office Actions on a series of applications for patents on expressed sequence tags, ESTs — could greatly complicate basic gene therapy research by substantially allowing patents for small sequences of a gene that may later be used by the patent holder to corner ownership and uses of entire genes.

So geneticists Stephen O'Rahilly and Sadaf Farooqi at the University of Cambridge, and colleagues, turned to a different kind of genetic variation, known as a deletion, in which entire genes are absent.

Until now, scientists wishing to delete a gene in a model organism like a mouse did it by clipping out stretches of DNA encoding entire genes or very big chunks of them from the animal's genome.

Kmiec also said that while other CRISPR tools are restricted to editing or repairing short segments of DNA code within a single gene, his team's new CRISPR tool could lead to applications that are capable of removing and replacing entire genes.

In the cobra's genome, entire gene families were repurposed to help produce a sophisticated, highly toxic mix of proteins and peptides that kept changing as prey evolved mechanisms to elude it.

But rather than delivering the entire gene for the clotting - factor proteins to cells, as most gene therapies do, the researchers used the viruses to engineer immune - regulating B cells to express a fragment of the clotting factor fused to an immune molecule called an immunoglobulin.

«Today, rapidly falling costs means that high throughput sequencing projects are revealing the entire gene sequences of ever more species, but the biological functions of most of these genes remain unknown,» said Dr. Olivier Lichtarge, professor of molecular and human genetics and director of the Computational and Integrative Biomedical Research Center at Baylor and senior author of the report.

In extreme cases, entire genes may be deleted or added.

With this quality control missing, the entire gene sequence is read as it spools through the ribosome.

One approach is to deliver a working copy of the entire gene within a virus, but this method can disrupt normal genes.

«Mutations in epilepsy tend to affect specific areas of the gene, whereas mutations associated with intellectual disability are more often distributed throughout the entire gene.

Should you cut it at the beginning of the coding sequence to delete the entire gene?

That can make it hard to make subtle changes to a gene — like introduce point mutations corresponding to natural variations linked with human disease — without taking a sledgehammer to the entire gene locus.

It is important to note whether a test interrogates a set of common variants, or sequences entire genes (and identifies both common and rare variants).

Panel tests should report not only single - nucleotide variants and small indels, but also structural variants (deletions and duplications) that might span exons or entire genes.

So in the process of copying the DNA into RNA, first a copy is made of the entire gene, and then the non-coding regions are removed from RNA, in a process called splicing.

Finally, to make sure that E2 enhancer loss mimicked deletion of the entire gene in monocytes the group revisited a tumor model previously used to test Nr4a1's anti-cancer effect.

In addition to specific disease research, CHF funds the gargantuan canine genome project to map the entire gene code of man's best friend.

His program, «Ma3a,» has AI sophisticated enough to store the entire gene code of a person and the mathematical equations necessary to transfer people back and forth between the...