In addition to specific disease research, CHF funds the gargantuan canine genome project to map
the entire gene code of man's best friend.
Not exact matches
They isolated its
entire genetic
code — one chromosome that forms a circle — stripping it of all its proteins, and then added
genes to make a host organism blue (to make it easy to pick out in a Petri dish) as well as resistant to the antibiotic tetracycline.
They sequenced the
entire nuclear genome of this species, and identified all of the
genes within that genome that
code for biological functions.
The human genome contains about 3 billion base pairs, but only about 2 percent of these base pairs represent protein -
coding genes, meaning that whole - exome sequencing measures the genetic alterations focused on a small but very important fraction of the genome (as opposed to techniques of whole genome sequencing, which measures every nucleotide across the
entire genome, regardless of whether these
genes are expressed or silent).
The branch uniting the fungi and animals is well - supported based on a number of molecular phylogenetic datasets, including the nuclear small subunit ribosomal RNA
gene (Wainwright et al., 1993; Bruns et al. 1993), unique and shared sequence insertions in proteins such as elongation factor 1α (Baldauf and Palmer, 1993),
entire mitochondrial genomes (Lang et al., 2002), and concatenated protein -
coding genes (Steenkamp et al., 2006).
Should you cut it at the beginning of the
coding sequence to delete the
entire gene?
The DNA we can retrieve from passenger pigeon specimens is too fragmented to reassemble the
entire genomic
code — but we can map the sequence of
genes and
gene regulating regions that are most important to creating passenger pigeon traits.
Her game - changing technology takes a mysterious bacterial genetic
code and transforms it into a powerful tool for cutting and pasting bits of genetic material — meaning not only could the
entire field of
gene therapy be revived, but her genome - editing tool could one day be used to treat a range of diseases, from cancer and AIDS to hereditary disorders like Down syndrome and Huntington disease.
The
entire coding region of the progranulin
gene was deleted in the null allele.
The researchers then analyzed another 147 colorectal cancer cell lines in the same way for kinase - domain mutations in these
genes, and then sequenced the
entire coding region of all kinases that were mutated, in all discovering 46 new mutations.
Kmiec also said that while other CRISPR tools are restricted to editing or repairing short segments of DNA
code within a single
gene, his team's new CRISPR tool could lead to applications that are capable of removing and replacing
entire genes.
This will include robotic DNA extraction, genome - wide mapping with high density
gene chips (querying 175,000 DNA markers), and next - gen sequencing of the
entire genome of an affected dog (interrogating every letter of the 2.4 billion letter genetic
code).
The DNA we can retrieve from passenger pigeon specimens is too fragmented to reassemble the
entire genomic
code — but we can map the sequence of
genes and
gene regulating regions that are most important to creating passenger pigeon traits.