We are also interested in the analyses that are beginning to emerge following the availability of
the entire genome sequences of several organisms.
Meanwhile, another team — reporting in Science Express today — has described
the entire genome sequences of a mother and father (both healthy) and their two children, both of whom have two inherited disorders: Miller syndrome and primary ciliary dyskinesia.
To retrace the history of the disease, an international team of scientists, led by Johannes Krause from Tübingen University and Stewart Cole from EPFL Lausanne, have reconstructed
entire genome sequences of M. leprae bacteria from five medieval skeletons that were excavated in Denmark, Sweden and the United Kingdom as well as seven biopsy samples from modern patients.
Having
the entire genome sequence of any organism accelerates the pace of biological research.
Not exact matches
The
entire genome of the tiny nematode (Caenorhabditis elegans) also has been
sequenced as a ta - ngen = tial study to the human
genome project.
In June 2000 he and Craig Venter
of the rival commercial project were able jointly to announce the
entire sequencing of the human
genome.
CSIRO is part
of an international consortium to
sequence the
entire genome of sugarcane.
«To better understand the functions
of the
genome, it would be useful to have the
entire catalog
of all the RNA molecules that interact with DNA, and what
sequences they interact with.
New DNA recovery and
sequencing technology is at last allowing scientists to assemble
entire genomes of ancient scourges — and elusive modern ones
The human
genome contains millions
of sequences derived from so - called transposable elements, genetic units that «jump» around the
entire genome.
A 2010 study led by Hood in collaboration with the University
of Washington and the University
of Utah
sequenced the
entire genomes of four family members.
In the new study, the researchers
sequenced the
entire genome of mice that had undergone CRISPR gene editing in the team's previous study and looked for all mutations, including those that only altered a single nucleotide.
A decade ago,
sequencing the dna in a person's
entire genome cost up to $ 1 billion, a price so prohibitive that only a few genetics pioneers had the honor
of having it done.
Now Pääbo and his colleagues have devised a new method
of genetic analysis that allowed them to reconstruct the
entire Denisovan
genome with nearly all
of the
genome sequenced approximately 30 times over akin to what we can do for modern humans.
By
sequencing the
entire genome of 30 African honeybees, the research team has been able to study recombination at a level
of detail not previously possible.
If all this sounds wildly implausible, bear in mind that the idea
of sequencing an
entire human
genome in days seemed nigh on impossible just a few years ago.
George Church, another Harvard geneticist, is working to speed up the
sequencing and analysis
of a person's
entire genome.
His team synthesised small pieces
of DNA with a specific
sequence, and then joined them together to create an
entire genome.
Scientists have
sequenced the
entire genome of Chlamydia trachomatis, the enigmatic bacterium that's the leading cause
of venereal disease in the United States.
Roughly speaking, ChIP
sequencing can be compared to a microscope, which enables us to observe the presence
of different cell components in the
entire genome at a given time.
Aedes has many repetitive
sequences and transposable elements (sections that can wander freely within the
genome), making it difficult to accurately reassemble the
entire set
of DNA
sequences.
The scientists obtained fragments
of the viral genetic material from the insect samples and joined these fragments together like a puzzle, thus reconstructing the
entire genome sequence.
Sequencing of a patient's
entire genome or exome — the part
of the
genome used to build proteins — now offers an effective strategy to pinpoint culprit mutations and make an accurate diagnosis.
Researchers from the University
of Edinburgh's Roslin Institute, which receives strategic funding from the Biotechnology and Biological Sciences Research Council, were part
of a global team that has decoded the
genome sequence — the
entire genetic make - up —
of domestic sheep for the first time.
«Previous studies have given us a broad set
of benchmarks, including the
sequence of the
entire genome, which makes Candida albicans a great subject for study in microgravity because we have extensive information to compare it to.»
In order to locate all gene switches, the Freiburg research team used modern
sequencing methods to examine the
entire genome — DNA, epigenetic markers and RNA — during the development, maturation and disease
of human cardiac muscle cells.
When James Watson, co-discoverer
of the double - helix structure
of DNA, had his
entire genome sequenced in 2007 it cost around $ 1 million.
For the first time last year, Sandia microbiologists studying infectious diseases
sequenced the
entire genome of a Klebsiella pneumoniae strain that encodes New Delhi metallo - beta - lactamase (NDM - 1).
A genetic analysis, which included
sequencing the
entire genome of Cephalotus, found strong evidence that during their evolution into carnivores, each
of these plants co-opted many
of the same ancient proteins to create enzymes for digesting prey.
They
sequenced the
entire nuclear
genome of this species, and identified all
of the genes within that
genome that code for biological functions.
If mutations occur at random over the
entire sequence of a species»
genome, how can a complex organ such as an eye evolve?
Powered by advances in
sequencing technology, the field
of ancient DNA has succeeded beyond all expectations, helping researchers to retrieve the
entire genomes of Neandertals and other kinds
of ancient humans and transforming the picture
of human evolution.
Researchers used various DNA
sequencing machines to produce very small pieces
of the
entire genome, Gmitter said.
First, iCAGES analyzes the patient's
entire genome, comparing it to the genomic
sequence of the patient's tumor to identify possible cancer - causing variants.
In April researchers reported
sequencing the
entire genome of DNA pioneer James Watson, a project that took only two months and cost less than $ 1 million.
Now, thanks to cheap
genome sequencing, deCODE has
sequenced the
entire genomes of 2636 Icelanders and combed them for much rarer mutations.
The first study to
sequence and analyze the
entire genome of a HeLa cell line, along with access to its
sequence data, has been published Aug. 7 in its final version, by G3: Genes
Genomes Genetics, an open - access, scientific journal
of the Genetics Society
of America.
The researchers
sequenced the
entire genome of C. amylolentus, mapping the location
of all the genes as well as the centromeres on each
of the organism's 14 chromosomes.
His automated
genome - sequencing machine is driving the price of mapping a person's entire genetic code down toward $ 1,000, almost unbelievably cheap considering that, less than a decade ago, the government - funded Human Genome Project spent roughly $ 3 billion to sequence a single g
genome -
sequencing machine is driving the price
of mapping a person's
entire genetic code down toward $ 1,000, almost unbelievably cheap considering that, less than a decade ago, the government - funded Human
Genome Project spent roughly $ 3 billion to sequence a single g
Genome Project spent roughly $ 3 billion to
sequence a single
genomegenome.
«Even though we've
sequenced the
entire genome of Plasmodium falciparum, half
of it still remains functionally uncharacterized.
The third is a method implemented by Reich for reading the genetic codes
of 1.2 million carefully chosen variable parts
of DNA (known as single nucleotide polymorphisms) rather than having to
sequence entire genomes.
His group is now
sequencing the
entire Neandertal
genome and in the 21 August issue
of the Proceedings
of the National Academy
of Sciences describes the steps taken over the past year to lessen the odds
of contamination.
In a few years prenatal whole -
genome sequencing will provide the
entire genetic code
of an unborn fetus, alerting parents
of possible genetic diseases their child may have or develop.
A research team from Uppsala University has
sequenced the
entire genomes of a sample
of Cape bees and compared them with other populations
of honeybees to find out the genetic mechanisms behind their asexual reproduction.
As part
of a long - standing effort to study the rampant drug - resistant TB in Samara, a region
of Russia about 1,000 kilometers southeast
of Moscow, researchers collected TB isolates from 2,348 patients and
sequenced the
entire genomes of 1,000
of them.
Now, Timothy Read at The Institute for Genomic Research (TIGR) in Rockville, Maryland, and colleagues have
sequenced the
entire Florida strain and compared it to the
genome of the so - called Porton strain.
Using a technique called whole -
genome random
sequencing, a TIGR team mapped the
entire two - million - gene
sequence of Thermotoga maritima, a bacterium first plucked from hot geothermal springs in Vulcano, Italy.
As the cost
of sequencing an
entire genome drops, the day will soon arrive when documenting a full record
of a patient's DNA may become as routine as a cholesterol test.
The human
genome contains about 3 billion base pairs, but only about 2 percent
of these base pairs represent protein - coding genes, meaning that whole - exome
sequencing measures the genetic alterations focused on a small but very important fraction
of the
genome (as opposed to techniques
of whole
genome sequencing, which measures every nucleotide across the
entire genome, regardless
of whether these genes are expressed or silent).
Chaput's method
of studying such
sequences on a
genome - wide scale involves first generating a DNA library
of the
entire human
genome.