Results show that direct stimulation of
the entorhinal area successfully improved hippocampal - dependent memory across a wide range of memory tasks (verbal recall, spatial navigation, face - name memory, and person / object recognition) with stimulation site (entorhinal white / gray) as the critical determinant of subsequent memory performance independent of antiepileptic medication (on / off), side (left / right) or type (macro / micro) of stimulation.
Nanthia Suthana will present work showing that the precise location of electrical stimulation delivered to
the entorhinal area is critical in enhancing performance on a wide - range of hippocampal - dependent memory tasks.
Thank you for submitting your article «Theta - burst microstimulation in the human
entorhinal area improves memory specificity» for consideration by eLife.
Microstimulation in the right
entorhinal area during learning significantly improved subsequent memory specificity for novel portraits; participants were able both to recognize previously - viewed photos and reject similar lures.
We show that theta - burst microstimulation of the right
entorhinal area, applied prior to stimulus onset, enhanced memory specificity for these photographs.
Neuropsychological data suggest that the left medial temporal lobe is better suited to verbal learning32 and that the right medial temporal lobe is better suited to nonverbal (e.g., visuospatial) learning.33 Although two subjects in our study had stimulation in the left
entorhinal area, our study is too small to support conclusions about laterality effects.
Thus, there were six tests of retention of memory after stimulation of
the entorhinal area and six tests of retention of memory after stimulation of the hippocampus.
Theta - burst microstimulation in the human
entorhinal area improves memory specificity.
Advancements in intracranial stimulation of
the entorhinal area for enhancement of episodic memory.
Memory enhancement and deep - brain stimulation of
the entorhinal area.
Not exact matches
Some people's electrodes were in the
entorhinal cortex's gray matter, and some were in its white matter fibers, which extend to the hippocampus, an
area known for its role in memory.
A rat's position in space can be represented in the medial
entorhinal cortex in addition to the neighboring hippocampus, the
area previously thought to be the only locus of spatial information.
To determine how information is represented in this
area, we measured spatial modulation of neural activity in layers of medial
entorhinal cortex projecting to the hippocampus.
Regardless of gender, young adults who have greater aerobic fitness also have greater volume of their
entorhinal cortex, an
area of the brain responsible for memory.
In contrast, the researchers did not find age - related differences in another
area of the brain connected to memory, the posteromedial
entorhinal cortex.
«Immediately after the rat is exposed to the smell there is a burst in activity of 20 Hz waves in a specific connection between an
area in the
entorhinal cortex, lateral
entorhinal cortex (LEC), and an
area in the hippocampus, distal CA1 (dCA1), while a similar strong response was not observed in other connections,» Igarashi explains.
In order to see what happened inside the brain during acquisition, 16 electrode pairs were inserted in the hippocampus and in different
areas of the
entorhinal cortex.
To determine whether direct
entorhinal connections support spatial firing and spatial memory, we removed all input from
areas CA3 to CA1, thus isolating the CA1
area.
Our studies help us to understand how the nerve cells in the
entorhinal cortex operate and how electrical activities might get interrupted in this
area of the brain.»
«It's what would be expected based on the physiological characteristics of that
area of the brain,» which is known as the
entorhinal cortex and is the first brain region to break down in Alzheimer's disease.
Unlike the visual cortex, say, whose coding will be influenced by light falling onto the retina, the
entorhinal cortex creates the hexagonal pattern entirely internally, by integrating whatever information about the environment is received by other
areas of the brain.
Direct projections from the septal
area to hippocampal interneurons also play a role in generating theta waves, but their influence is much smaller than that of the
entorhinal inputs (which are, however, themselves controlled by the septum).
The medial septal
area projects to a large number of brain regions that show theta modulation, including all parts of the hippocampus as well as the
entorhinal cortex, perirhinal cortex, retrosplenial cortex, medial mamillary and supramamillary nuclei of the hypothalamus, anterior nuclei of the thalamus, amygdala, inferior colliculus, and several brainstem nuclei (Buzsáki, 2002).
The
entorhinal cortex is one of the first
areas to be affected in AD and is the main connection between the hippocampus and neocortex playing an important role in spatial memory [82].
They also monitored two other
areas of the brain, the hippocampus and the
entorhinal cortex, as control regions because they «weren't expecting any stimulus preference there,» Mormann said via email.