Sentences with phrase «enzyme expressing cells»

The team went on to show that supplementing heavy stable isotope - labeled forms of these precursors led to incorporation of heavy amino acids into proteins produced in enzyme expressing cells.

Not exact matches

The enzyme at the center of this study, ADAR1, is normally expressed during fetal development to help blood cells form.

Bacteria expressing enzyme in one cell (bright green), while genetically identical cells do not, remaining protected from antibiotic onslaught; image courtesy of Yuichi Wakamoto / Neeraj Dhar / John McKinney Some strains of nasty bacterial infections, such as MRSA (methicillin - resistant Staphylococcus aureus), come loaded with resistance to antibiotics built right into their genes.

The enzyme has the novel ability to convert a chemical, metronidazole, into a toxin, which allows researchers to selectively kill the cells expressing it.

Telomerase, the enzyme that repairs telomeres, is only active during pregnancy; i.e. healthy cells in an adult organism do not express telomerase.

The treatment is based on making bone marrow cells express the telomerase enzyme, which is responsible for repairing telomeres.

Gauthier, Miller and co-workers engineered cells to express amino acid biosynthesis enzymes, which enabled cells to grow on their own supply of amino acids produced from supplemented precursors.

However, examining OS tumours the research team behind the new results found that OS cancer cells express special enzymes and receptors, enabling them to degrade bone tissue themselves.

As these cells rapidly proliferate, they also express high levels of an enzyme known as activation - induced cytidine deaminase (AID), which induces mutations in their DNA.

The point mutation was induced by forming a synthetic complex through removal of nuclease activity from the CRISPR system — a technique using artificial nuclease — and addition of deaminase, a deaminizing (base - modifying) enzyme, and then expressing it in yeasts and mammalian cells.

When the team forced regions such as the developing nervous system to express the enzyme, the germ cells journeyed there rather than to the gonads.

When expressed normally, the protein acts as an enzyme at the cell membrane, instigating a complex biochemical reaction that regulates the cell cycle and prevents cells from growing or dividing in an unregulated fashion.

To overcome this, researchers from the University of Texas Southwestern Medical Center and Johns Hopkins University stabilized pri - miRNAs by expressing a dominant negative form of DROSHA, the RNase III enzyme responsible for pri - miRNA cleavage, in a variety of human and mouse cell lines.

RNAi knockdown of KMO - 1, an enzyme involved in ommochrome synthesis that is expressed in pigment cells, leads to alterations in body color and increased porphyrin levels.

The authors report that genes encoding heme synthetic enzymes (that generate porphyrin intermediates) are expressed in pigment cells, and the first three enzymes in the heme synthetic pathway are also required for proper pigmentation.

Laminin cultured cells arrange themselves in lobule like structures, express MRP1 and MRP2 and are capable of biliary efflux and show significant effect on hepatocyte P450 enzyme metabolic activity.

This subtype, named by the authors «senescence - associated macrophages» or SAMs, share some biomarkers of senescent cells by expressing p16 (Ink4a) gene and an enzyme beta - galactosidase.

Podophyllotoxin does not inhibit COX - 2, but when tethered to a drug that does, it accumulates in enzyme - expressing cancer cells.

The donor luciferase enzyme can be expressed on the N - terminus of the receptor of interest in an appropriate transfected cell line.

Since invasion is dependent on extracellular matrix remodeling capabilities, this inhibitory effect strongly suggested that the two key extracellular membrane remodeling enzymes expressed by endothelial cells, namely, MMP - 2 and uPA could be other main key targets of the pharmacological action of kahweol on endothelial cells.

All proteins were expressed in HEK293E cells as soluble fusion proteins that contained a C - terminal rat Cd4 (d3 + 4)- hexahistidine tag for purification and could be optionally monobiotinylated by cotransfecting a secreted version of the E. coli BirA enzyme [33].

I need help on how to generate a stable neuronal cell line expressing prion protein via pre-transfection restriction enzyme digestion of plasmid DNA using lipid reagent.

Maybe because people eating plant - strong diets express more of the fat shoveling enzyme inside the power plants — the mitochondria — within our cells (How to Upregulate Metabolism).

Maybe it's because people eating plant - strong diets express more of the fat - shoveling enzyme inside the power plants inside the mitochondria within their cells.

Studies show that human cancer cells express high levels of the fatty acid synthase enzyme, which is associated with aggressive tumor behavior and tumor - cell growth.