Sentences with phrase «ephrin binding»

(A) Peptides targeting the Eph receptors can function as antagonists that inhibit ephrin binding and receptor signaling, or in some cases as agonists that mimic the ephrins by activating Eph receptor signaling.

These activities are independent of ephrin binding and / or kinase activity and their mechanism is not well understood but in some cases depends on Eph receptor phosphorylation on serine / threonine residues (red circle).

(A) Eph receptor - ephrin binding at cell - cell contact sites results in the dimerization / clustering of Eph receptor - ephrin complexes, and initiation of canonical signals through the receptor cytoplasmic domain.

Studies by ours and other groups have shown that a number of EphA2 and EphA3 mutations inactivate Eph receptor canonical signaling by disrupting ephrin binding or kinase activity, consistent with a role of canonical signaling in tumor suppression.

Not exact matches

Eph receptors and their binding partners, the ephrins, are found on the surface of almost all cell types.

For intance, GluA2 binds to PDZ domains 4 and 5 (Dong et al 1997), while ephrin receptors bind to domains 6 and 7 (Torres et al 1998).

Binding to ephrin ligands on the surface of neighboring cells induces canonical signaling involving receptor clustering, autophosphorylation on tyrosine residues, and kinase activity - dependent downstream signaling.

This is unlike the natural ephrin ligands, each of which promiscuously binds to multiple Eph receptors.

Peptides can target the ephrin - binding pocket of Eph receptors with high affinity and specificity, affecting receptor function.

Binding to the Eph receptors can also cause the ephrins, which have a cytoplasmic domain or a GPI - anchor, to transmit signals.