Sentences with phrase «ephrin system»
Understanding the effects of Eph receptor mutations in cancer cells will help shed light on the role of the Eph receptor / ephrin system in cancer cell transformation, malignant progression and drug resistance.
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In addition, the ephrin - Eph system also plays a role in plastic processes, such as learning and regeneration, as well as in tumour growth and neurodegenerative diseases.
One way this communication happens is through the ephrin / Eph - receptor system, which is able to guide cell migration and the growth of neuronal extensions.
«This is why it's so fundamentally important to understand how cells use this system to communicate,» says Rüdiger Klein, whose Department at the Max Planck Institute of Neurobiology is studying ephrins and Eph receptors.
In the 1990s, scientists found the first of those signaling systems, a family of ephrin proteins that are present in graded fashion in the brain and are involved in axon guidance.
Receptor tyrosine kinases of the Eph family and their ligands, the ephrins, represent an important cell communication system that controls a vast array physiological and disease processes.