Sentences with phrase «ephrins using»
We have identified tyrosine and serine / threonine phosphorylation sites of Eph receptors and ephrins using mass spectrometry and investigated the signaling role of these phosphorylation sites.
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«This might mean that strategies to control exosome release could be used to interrupt the ephrin - Eph signaling pathway and thereby disrupt tumour growth,» he surmises.
Recently, however, ephrins and Eph receptors have also been found in extracellular vesicles / exosomes — small droplets of fat released by cells, used as transport vehicles, signal transmitters or for eliminating cell components.
«This is why it's so fundamentally important to understand how cells use this system to communicate,» says Rüdiger Klein, whose Department at the Max Planck Institute of Neurobiology is studying ephrins and Eph receptors.
We discovered several Eph receptors and ephrins, and research in our laboratory is dedicated to the characterization of Eph receptor signal transduction mechanisms and biological functions using biochemical, mass spectrometry, molecular biology and cell biology approaches in conjunction with animal models.