Effects of telomerase and telomere length on
epidermal stem cell behavior.
Epidermal stem cells from mouse tail skin visualized by wholemount 3D immunostaining: Left panel shows
epidermal stem cells marked with BrDU (Label Retaining Cells); Middle and right panels Show expression of keratin - 15 and high expression of integrin alpha6, respectively.
4
Epidermal Stem Cell Lab, Department of Bioscience Technology, Chung Yuan Christian University, Chung - Li, Taiwan
Basic fibroblast growth factor reduces scar by inhibiting the differentiation of
epidermal stem cells to myofibroblasts via the Notch1 / Jagged1 pathway.
Human epidermis has been produced in vitro for decades using adult
epidermal stem cells from donors to provide cell therapy.
«If you have a gene correction strategy,» he says, «you'd better have these primitive
epidermal stem cells in mind.»
«It makes considerable headway in resolving a brewing controversy in
the epidermal stem cell field» over exactly how the skin regenerates, she says.
Not exact matches
Interestingly, they found that
stem cells coming from different
epidermal compartments present very similar response during wound repair, despite the fact that they are recruited from different regions of the epidermis.
Importantly, the new technique grows the pluripotent
stem cells as floating spheres in high concentrations of two growth factors, fibroblast growth factor - 2 and
epidermal growth factor.
Human
epidermal equivalents representing different types of skin could also be grown, depending on the source of the
stem cells used, and could thus be tailored to study a range of skin conditions and sensitivities in different populations.»
Earlier work hinted that skin follicles harbor
stem cells kept in reserve to replace
epidermal cells when they die.
De Luca's team used a patch of skin a little bigger than a U.S. postage stamp from an unblistered part of the boy's groin to culture
epidermal cells, which include
stem cells that periodically regenerate the skin.
Derivation of pluripotent
stem cells, either of embryonic origin or following genetic reprogramming, has opened the path for an alternative source for
epidermal cell therapy as these cells are both immortal and pluripotent, theoretically capable of providing any requested number of cells of any desired phenotype.
We find that crustacean limb regeneration relies lineage - committed progenitor cells: muscles derive from satellite - like
stem cells, whereas epidermis regenerates from existing
epidermal cells.
The Jones group project examines
epidermal and oesophageal
stem cells.
The
stem cells display self - renewal capacity and differentiate into neural crest derivatives including
epidermal pigment - producing melanocytes.
Recently, the
epidermal cells in the Arabidopsis shoot
stem cell niche were quantified to assess cell size regulation triggering cytokinesis.
The research, described in the journal
Stem Cells under the title «Reprogramming Postnatal Human
Epidermal Keratinocytes Toward Functional Neural Crest Fates,» was supported by grants from the National Institutes of Health.
By turning on a single gene, researchers can prevent skin
stem cells from maturing into the three types of adult skin cells —
epidermal, sebaceous and hair cells.
Stem cell marker aldehyde dehydrogenase 1 - positive breast cancers are characterized by negative estrogen receptor, positive human
epidermal growth factor receptor type 2, and high Ki67 expression
Peptides,
stem cells, vitamins and Bio-Suisse extracts instantly firm and lift skin while maximizing full - face collagen production and
epidermal nourishment — the key to helping skin retain its youthful appearance.
Title: Transplantation and Tracking of Autologous
Epidermal Neural Crest
Stem Cells into the Spinal Cord of Dogs with Acute Severe Spinal Cord Injury