Epidermal stem cells from mouse tail skin visualized by wholemount 3D immunostaining: Left panel shows epidermal stem cells marked with BrDU (Label Retaining Cells); Middle and right panels Show expression of keratin - 15 and high expression of integrin alpha6, respectively.
Human epidermis has been produced in vitro for decades using adult
epidermal stem cells from donors to provide cell therapy.
Not exact matches
Interestingly, they found that
stem cells coming
from different
epidermal compartments present very similar response during wound repair, despite the fact that they are recruited
from different regions of the epidermis.
De Luca's team used a patch of skin a little bigger than a U.S. postage stamp
from an unblistered part of the boy's groin to culture
epidermal cells, which include
stem cells that periodically regenerate the skin.
We find that crustacean limb regeneration relies lineage - committed progenitor
cells: muscles derive
from satellite - like
stem cells, whereas epidermis regenerates
from existing
epidermal cells.
The research, described in the journal
Stem Cells under the title «Reprogramming Postnatal Human
Epidermal Keratinocytes Toward Functional Neural Crest Fates,» was supported by grants
from the National Institutes of Health.
By turning on a single gene, researchers can prevent skin
stem cells from maturing into the three types of adult skin
cells —
epidermal, sebaceous and hair
cells.