To identify those substances, researchers add melanocytes to
the epidermis model.
Substances are tested on a mature
epidermis model by applying them to the surface of the epidermis and exposing the model to defined, but non-toxic, doses of UV radiation.
A fully developed
epidermis model is used to study phototoxic effects.
Not exact matches
Tissue engineers have been unable to grow
epidermis with the functional barrier needed for drug testing, and have been further limited in producing an in vitro (lab)
model for large - scale drug screening by the number of cells that can be grown from a single skin biopsy sample.
The new
epidermis, grown from human pluripotent stem cells, offers a cost - effective alternative lab
model for testing drugs and cosmetics, and could also help to develop new therapies for rare and common skin disorders.
We focus on squamous tissues, the skin
epidermis and the lining of the oesophagus, using transgenic
models, novel sequencing approaches, live imaging and single cell analysis to uncover key steps in cancer development, with aim of developing rational interventions to decrease cancer risk.
Single phenotypic traits measured and extracted in the cortex at day 6 postgermination could be all fitted by the three
models as well, similarly as showed for the
epidermis (Fig 3A, n = 40, Tables EV3 and EV4).
I can't help but think the Namibian and Mongolian
models seem a lot more natural; and if the recent research into «the hidden universe of organisms (bacteria, viruses and fungi) teeming throughout our glands, hair follicles and
epidermis» is accurate, then it's also much healthier.