Sentences with word «epigenetic»

The project's goals were to explore and describe the range of epigenetic changes that take place in bone marrow as stem cells develop into different types of mature blood cell.

Other chemicals can interfere with epigenetic marks in embryos.

Results of animal work can not be translated directly to humans, but initial findings of recent research suggest an effect of parental care on epigenetic regulation in the human brain.

Studies on epigenetic effects on diabetes risk in humans are scarce; thus, we mostly rely on studies on rodents.

In addition, he says, the modern revolution in gene sequencing has revealed many mutations in cancers that control epigenetic factors.

These changes, known as epigenetic modifications, control the activity of our genes without changing the actual DNA sequence.

The researchers propose that this type of epigenetic effect could be of importance in dealing with allergic disease.

In animal models, maternal diet alters offspring body composition, accompanied by epigenetic changes in metabolic control genes.

Turns out genes have what are called epigenetic markers.

They then looked at various epigenetic markers in the sperm.

The research centre currently consists of seven groups studying epigenetic mechanisms regulating cellular differentiation programs.

The second aspect deals with the importance of epigenetic processes in the female germ line.

Through epigenetic inheritance, some of the experiences of the parents may pass to future generations.

The team looked at epigenetic changes, which do not affect the genetic code itself but which influence the activity of genes.

Early - life adversity - induced long - term epigenetic programming associated with early onset of chronic physical aggression: Studies in humans and animals.

Six patients were treated first with epigenetic therapy followed by immune therapy.

One such surprise was the relative importance of two types of epigenetic control switches for retinal development.

Beyond the DNA sequence, so - called epigenetic information contributes to the control of gene expression.

The brain attempts to adapt and respond to those challenges and that occurs in large part through changes in expression of brain genes through epigenetic mechanisms.

One line of research traces memory loss in old age to epigenetic alterations in brain neurons.

Within so - called epigenetic research, several studies have suggested that human precursor cells have a memory of past environmental exposures.

My long - term career goal is to lead a successful independent academic lab studying how epigenetic regulation contributes to normal biology and disease pathology, particularly in repeat diseases.

This activation is achieved by proteins called epigenetic regulators, which work to make specific regions of our genome more or less accessible to transcription.

Results indicated that intervention effects on reductions in harsh parenting accounted for the association between parental depression levels and slower epigenetic aging among offspring.

The researchers believe there are other disease entities, aside from cancers, that may be significantly affected by targeted epigenetic therapies.

Even in the womb, epigenetic influences can change the developing brain in ways that increase the risk of eventual suicide.

Consumers will be able to receive actionable recommendations of optimized skincare products to use, as well as assess the progress of their skincare routines, based on their skin's epigenetic profiles.

Older dads seem to pass on health risks via epigenetic tags on the DNA in their sperm.

We have a specific example of epigenetic memory that is passed on, and we can see it in the microscope.

As such, we've already figured out how some factors cause epigenetic changes.

How does regulation of gene expression determine inner ear function on a genetic and epigenetic level?

-- We have identified epigenetic signatures that separate patient groups depending on different disease outcome.

But it can be difficult to establish a causal connection between epigenetic changes and changes in behavior and health.

There is no doubt that some animals respond to the environment via epigenetic mechanisms, he says, but these mechanisms have evolved via genetic changes.

At least eight other epigenetic drugs are currently in different stages of development or human trials.

A prime spot to go looking for ancient epigenetic signals is in permafrost that formed during the last ice age.

Such epigenetic marks play a central role in the regulation of the genome's expression.

Understanding epigenetic mechanisms and their contribution to the persistence of diabetic complications is critical because it could suggest alternative targets for therapy to halt and reverse complications.

His lab continues to study the genetic and / or epigenetic basis for the differences between leader and follower cells.

Finally, we can't control for other epigenetic changes.

An international team of researchers has developed a novel compound that successfully inhibits growth of melanoma cells by targeting specific epigenetic modifying proteins in these cells.

The researchers are now looking at whether epigenetic effects no longer have an impact on great - grandchildren and their subsequent offspring.

They analyzed two epigenetic phenomena along the entire genome and compared the results for each set of twins.