Supportive Family Environments Ameliorate the Link Between Racial Discrimination and
Epigenetic Aging.
Results indicated that intervention effects on reductions in harsh parenting accounted for the association between parental depression levels and slower
epigenetic aging among offspring.
The purpose of this study was to determine whether the Strong African American Families (SAAF) heightened parental depressive symptoms would forecast accelerated
epigenetic aging for youths.
Limitations include SAAF trial was not designed with
epigenetic aging as an endpoint, may not be generalizable to rural African American families in other geographic regions or from dissimilar socioeconomic backgrounds, and lack of follow - up.
Family - centered prevention ameliorates the longitudinal association between risky family processes and
epigenetic aging.
Also, they are careful to say, now, that intend to improve ill - health but as we know from
epigenetic aging, these concepts can untangled and uncoupled; and thus, remaining healthy would theoretically allow eternal life; but that is something
epigenetic aging has answers that are more muddled and less hopeful.
It may be that, most likely, 5 of the therapies will impact health to nullify many disease but will not change the «aging» process (the one that is disconnected from telomeres but related with epigenetics) and 2 last therapies will be of intrinsic aging, of which one could end up not doing anything but remain a mitochondrial improvement manifesting as removal of mitopathies (such as MELAS) but would not alter the course of aging (such as the seperate
epigenetic aging going on).
I am fearing this part (
epigenetic aging) is omething SENS should add as 8th therapy, very important.
Health improvement (allowing to post - pone / escape the diseases and thus live, healthier / disease - free longer, but not above human MLSP of around 122 years; thus these therapies do not affect
epigenetic aging whatsoever, they are degenerative aging problems not regular healthy aging problem (except OncoSENS - only when you Already Have Cancer - which cancer increases
epigenetic aging, but cancer removal thus does not change anything / makes no difference about what happens in the other cells / about what happens in the normal epigenetic «aging» course in Normal non-cancerous healthy cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to MLSP).
It would technically allow eternal life, should we have infinite «replacement parts»; the challenge is making sure all these «parts» work together and we have the «least» amount of «repairing» going on to try to minimize «excessive invasion of the body with «Replacements» and end up «messing» things up (like a failed surgery procedure after than 100th one... there is this risk) OncoSENS - Stopping Cancer at the Starting Line (That is Extremely impressive, it will save so many lives, nothing more to add; and, perhaps one more thing, it will slow
epigenetic aging of Already cancer patients giving them hope to at least post pone it should it fail at eradicating it.)
«Genome wide association study of
epigenetic aging rates in blood reveals a critical role for TERT.»
Co-author Douglas P. Kiel, M.D., M.P.H, Director, Musculoskeletal Research Center and Senior Scientist at Hebrew SeniorLife's Institute for Aging Research said, «We calculated
the epigenetic aging rate for each person using a previously described epigenetic clock method.
In this genome - wide association study, researchers found gene variants mapping to five loci associated with intrinsic
epigenetic age acceleration (IEAA) and gene variants in three loci associated with extrinsic
epigenetic age acceleration.
The research team analyzed
the epigenetic age of up to 30 anatomic sites from the 112 - year - old woman.
Decreased
epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring.
«We can't conclude definitively from our study that the insomnia leads to the increased
epigenetic age, but these are powerful findings,» said Carroll.
Interestingly, their children also have younger - than - expected
epigenetic ages, which suggests they're aging more slowly, too.
Every iPSC line had a negative predicted
epigenetic age, as expected, but the team also noticed age - related variation.
92/2: 45 GWAS meta - analysis identifies susceptibility loci for
epigenetic age acceleration in human cerebellum.
Not exact matches
De novo mutations and
epigenetic changes could both be contributing factors in another recent study linking a father's
age to stillbirth, pre-term birth and low birth weight.
In both species, significant reductions in
epigenetic drift were observed, such that
age - related changes in methylation in old animals on the calorie - restricted diets were comparable to those of young animals.
The study suggests that
epigenetic changes drive the
aging process, and that those changes may be malleable.
A prime spot to go looking for ancient
epigenetic signals is in permafrost that formed during the last ice
age.
As the researchers showed, already at the
age of six weeks the Igfbp2 gene exhibited higher levels of methylation, i.e. stronger
epigenetic modification, and at the same time the IGFBP2 synthesis in the liver was significantly reduced.
«Our results indicate that the
epigenetic modification we studied makes both mice and humans more susceptible to obesity and with increasing
age increases their risk of developing a fatty liver,» said Anne Kammel, first author of the study.
One line of research traces memory loss in old
age to
epigenetic alterations in brain neurons.
How sleep apnea is related to these conditions is debated, but Cavadas and her co-authors propose that prolonged disruptions in blood oxygen levels and sleep fragmentation can generate stem cell exhaustion,
epigenetic changes, increased inflammation, and other hallmarks of
aging.
In addition, the Izpisua Belmonte team is developing
epigenetic editing technologies to reverse
epigenetic alterations with a role in human
aging and disease.
«For those people who
age more slowly, somehow their
epigenetic clock ticks more slowly,» Horvath says.
«There's an intrinsic process that drives
aging, and that may be what's captured by this
epigenetic clock.»
Our life experiences exert a profound influence on how we
age and can even alter the ways genes function without changing the underlying DNA sequence; these genetic changes are called
epigenetic traits.
Since then, he has used the
epigenetic clock as a tool to begin to understand the mechanics of
aging.
HIV - 1 infection accelerates
age according to the
epigenetic clock.
The cerebellum
ages slowly according to the
epigenetic clock.
Collectively,
epigenetic marks help package the genome into the loose but highly organized compartments it adopts during interphase, the working «middle
age» in the life of a cell.
Dr Ficz also explains that the findings could have an impact on our knowledge of
ageing and cancer: «
Epigenetic fluctuations happen all the time in our cells.
In order to work out which is the chicken and which is the egg, i.e. whether the
epigenetic changes are a consequence of the disease or if the disease is a result of the changes, the researchers also investigated whether healthy individuals had
epigenetic changes caused by
age, BMI and raised blood sugar levels.
The research group has previously shown that
age, diet and exercise affect the so - called
epigenetic risk of type 2 diabetes.
«We were able to observe that a number of
epigenetic changes had already taken place in healthy subjects as a result of
age or high BMI, and were therefore able to conclude that these changes could contribute to the development of the disease,» said Charlotte Ling.
«We know that nutrition, environment and
aging affects the DNA methylation pattern in our cells, including in egg cells,» states Wolf Reik, Head of the
Epigenetics programme at the Babraham Institute.
Instead we can use the
epigenetic clock to monitor their cells»
aging rate and to evaluate which therapies slow the biological
aging process,» explained Horvath.
Using the
epigenetic clock, they found that postmenopausal women with five insomnia symptoms were nearly two years older biologically than women the same chronological
age with no insomnia symptoms.
So the fact that only the
epigenetic signs of
aging are removed during cloning seems to verify the importance of
epigenetics in the
aging process.
His research is based on the concept that normal brain
aging and the pathogeneses of sporadic neurological diseases are not a consequence of a few single or «disease - specific «factors alone, rather they are driven by holistic events that include one's individual genetic and
epigenetic condition, progression of
aging, and lifestyle.
This week's features include: a clinic that doesn't know the difference between
epigenetics and genetics; lessons about
aging from Dolly the sheep; and does
epigenetics interfere with gene editing?
To this day, scientists are still learning valuable lessons about
aging, developmental biology, genetics and
epigenetics from Dolly and her four «sisters.»
A researcher at the Beatson Institute, Field explained that DNA's signs of
aging, such as environmentally induced mutations, don't disappear during the cloning process, but
epigenetic ones do.
Passaging the iPSCs gradually erased those donor cell
age - related
epigenetic differences, the team found.
I would wager they play about 20 - 30 % in impact (seen in diabetes
AGEs and glucosepane formation; again this where this is very touching on the DNA damage role and seperating from the
epigenetic role of
aging; they can be uncoupled making these DNA damage elements muddled and less important than previously thought (I'm only talking about healthy
aging, not pathological
aging (as in the diabetes, Diabetes will greatly improve by GlycoSENS.
Scientists have long realized that as people
age, their genomes undergo
epigenetic changes: some genomic sites gain methyl groups, others lose them.